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Table 4 Distribution of cardiovascular and other comorbidities among CRC cases and non-cases in 2002 and 2014

From: Trends in the contemporary incidence of colorectal cancer and patient characteristics in the United Kingdom: a population-based cohort study using The Health Improvement Network

  CRC cases   p-value Non-cases   p-value
2002 (N = 921) 2014 (N = 1330) % change   2002 (N = 1,125,723) 2014 (N = 1,756,868) % change  
n (%) n (%) n (%) n (%)
IHD 92 (10.0) 74 (5.6) −4.4 < 0.001 73,352 (6.5) 48,806 (2.8) −3.7 < 0.001
Hypertension 225 (24.4) 435 (32.7) + 8.3 < 0.001 176,647 (15.7) 339,158 (19.3) + 3.6 < 0.001
Hypercholesterolaemia 35 (3.8) 70 (5.3) + 1.5 0.106 37,220 (3.3) 82,270 (4.7) + 1.4 < 0.001
DVT/PE 33 (3.6) 37 (2.8) −0.8 0.282 20,408 (1.8) 27,139 (1.5) −0.3 < 0.001
Heart failure 30 (3.3) 30 (2.3) −1.0 0.147 17,086 (1.5) 16,112 (0.9) −0.6 < 0.001
Atrial fibrillation 33 (3.6) 82 (6.2) + 2.6 0.006 20,783 (1.8) 36,865 (2.1) + 0.3 < 0.001
MI 16 (1.7) 25 (1.9) + 0.2 0.804 15,651 (1.4) 17,206 (1.0) −0.4 < 0.001
Ischaemic stroke 12 (1.3) 20 (1.5) + 0.2 0.692 12,953 (1.2) 17,983 (1.0) −0.2 < 0.001
TIA 15 (1.6) 23 (1.7) + 0.1 0.855 12,642 (1.1) 15,200 (0.9) −0.2 < 0.001
Haemorrhagic stroke 3 (0.3) 5 (0.4) + 0.1 0.844 1418 (0.1) 2370 (0.1) 0.0 0.041
Anaemia 53 (5.8) 77 (5.8) 0.0 0.972 24,250 (2.2) 47,283 (2.7) + 0.5 < 0.001
Diabetes 79 (8.6) 231 (17.4) + 8.8 < 0.001 60,930 (5.4) 155,718 (8.9) + 6.5 < 0.001
Depression 66 (7.2) 86 (6.5) −0.7 0.515 106,405 (9.5) 171,204 (9.7) + 0.2 < 0.001
COPD 44 (4.8) 93 (7.0) + 2.2 0.031 24,696 (2.2) 64,071 (3.6) + 1.4 < 0.001
Asthma 92 (10.0) 157 (11.8) + 1.8 0.177 78,615 (7.0) 199,049 (11.3) +4.3 < 0.001
Osteoarthritis 146 (15.9) 196 (14.7) −1.2 0.468 123,356 (11.0) 157,758 (9.0) −2.0 < 0.001
Rheumatoid arthritis 13 (1.4) 14 (1.1) −0.3 0.442 10,383 (0.9) 18,234 (1.0) + 0.1 < 0.001
  1. CRC colorectal cancer, COPD chronic obstructive pulmonary disease, DVT deep vein thrombosis, IHD ischaemic heart disease, MI myocardial infarction, PE pulmonary embolism, TIA transient ischaemic attack