Table 4 Distribution of cardiovascular and other comorbidities among CRC cases and non-cases in 2002 and 2014
CRC cases | p-value | Non-cases | p-value | |||||
|---|---|---|---|---|---|---|---|---|
2002 (N = 921) | 2014 (N = 1330) | % change | 2002 (N = 1,125,723) | 2014 (N = 1,756,868) | % change | |||
n (%) | n (%) | n (%) | n (%) | |||||
IHD | 92 (10.0) | 74 (5.6) | −4.4 | < 0.001 | 73,352 (6.5) | 48,806 (2.8) | −3.7 | < 0.001 |
Hypertension | 225 (24.4) | 435 (32.7) | + 8.3 | < 0.001 | 176,647 (15.7) | 339,158 (19.3) | + 3.6 | < 0.001 |
Hypercholesterolaemia | 35 (3.8) | 70 (5.3) | + 1.5 | 0.106 | 37,220 (3.3) | 82,270 (4.7) | + 1.4 | < 0.001 |
DVT/PE | 33 (3.6) | 37 (2.8) | −0.8 | 0.282 | 20,408 (1.8) | 27,139 (1.5) | −0.3 | < 0.001 |
Heart failure | 30 (3.3) | 30 (2.3) | −1.0 | 0.147 | 17,086 (1.5) | 16,112 (0.9) | −0.6 | < 0.001 |
Atrial fibrillation | 33 (3.6) | 82 (6.2) | + 2.6 | 0.006 | 20,783 (1.8) | 36,865 (2.1) | + 0.3 | < 0.001 |
MI | 16 (1.7) | 25 (1.9) | + 0.2 | 0.804 | 15,651 (1.4) | 17,206 (1.0) | −0.4 | < 0.001 |
Ischaemic stroke | 12 (1.3) | 20 (1.5) | + 0.2 | 0.692 | 12,953 (1.2) | 17,983 (1.0) | −0.2 | < 0.001 |
TIA | 15 (1.6) | 23 (1.7) | + 0.1 | 0.855 | 12,642 (1.1) | 15,200 (0.9) | −0.2 | < 0.001 |
Haemorrhagic stroke | 3 (0.3) | 5 (0.4) | + 0.1 | 0.844 | 1418 (0.1) | 2370 (0.1) | 0.0 | 0.041 |
Anaemia | 53 (5.8) | 77 (5.8) | 0.0 | 0.972 | 24,250 (2.2) | 47,283 (2.7) | + 0.5 | < 0.001 |
Diabetes | 79 (8.6) | 231 (17.4) | + 8.8 | < 0.001 | 60,930 (5.4) | 155,718 (8.9) | + 6.5 | < 0.001 |
Depression | 66 (7.2) | 86 (6.5) | −0.7 | 0.515 | 106,405 (9.5) | 171,204 (9.7) | + 0.2 | < 0.001 |
COPD | 44 (4.8) | 93 (7.0) | + 2.2 | 0.031 | 24,696 (2.2) | 64,071 (3.6) | + 1.4 | < 0.001 |
Asthma | 92 (10.0) | 157 (11.8) | + 1.8 | 0.177 | 78,615 (7.0) | 199,049 (11.3) | +4.3 | < 0.001 |
Osteoarthritis | 146 (15.9) | 196 (14.7) | −1.2 | 0.468 | 123,356 (11.0) | 157,758 (9.0) | −2.0 | < 0.001 |
Rheumatoid arthritis | 13 (1.4) | 14 (1.1) | −0.3 | 0.442 | 10,383 (0.9) | 18,234 (1.0) | + 0.1 | < 0.001 |