| |
CRC cases
| |
p-value
|
Non-cases
| |
p-value
|
|---|
|
2002 (N = 921)
|
2014 (N = 1330)
|
% change
| |
2002 (N = 1,125,723)
|
2014 (N = 1,756,868)
|
% change
| |
|---|
|
n (%)
|
n (%)
|
n (%)
|
n (%)
|
|---|
|
IHD
|
92 (10.0)
|
74 (5.6)
|
−4.4
|
< 0.001
|
73,352 (6.5)
|
48,806 (2.8)
|
−3.7
|
< 0.001
|
|
Hypertension
|
225 (24.4)
|
435 (32.7)
|
+ 8.3
|
< 0.001
|
176,647 (15.7)
|
339,158 (19.3)
|
+ 3.6
|
< 0.001
|
|
Hypercholesterolaemia
|
35 (3.8)
|
70 (5.3)
|
+ 1.5
|
0.106
|
37,220 (3.3)
|
82,270 (4.7)
|
+ 1.4
|
< 0.001
|
|
DVT/PE
|
33 (3.6)
|
37 (2.8)
|
−0.8
|
0.282
|
20,408 (1.8)
|
27,139 (1.5)
|
−0.3
|
< 0.001
|
|
Heart failure
|
30 (3.3)
|
30 (2.3)
|
−1.0
|
0.147
|
17,086 (1.5)
|
16,112 (0.9)
|
−0.6
|
< 0.001
|
|
Atrial fibrillation
|
33 (3.6)
|
82 (6.2)
|
+ 2.6
|
0.006
|
20,783 (1.8)
|
36,865 (2.1)
|
+ 0.3
|
< 0.001
|
|
MI
|
16 (1.7)
|
25 (1.9)
|
+ 0.2
|
0.804
|
15,651 (1.4)
|
17,206 (1.0)
|
−0.4
|
< 0.001
|
|
Ischaemic stroke
|
12 (1.3)
|
20 (1.5)
|
+ 0.2
|
0.692
|
12,953 (1.2)
|
17,983 (1.0)
|
−0.2
|
< 0.001
|
|
TIA
|
15 (1.6)
|
23 (1.7)
|
+ 0.1
|
0.855
|
12,642 (1.1)
|
15,200 (0.9)
|
−0.2
|
< 0.001
|
|
Haemorrhagic stroke
|
3 (0.3)
|
5 (0.4)
|
+ 0.1
|
0.844
|
1418 (0.1)
|
2370 (0.1)
|
0.0
|
0.041
|
|
Anaemia
|
53 (5.8)
|
77 (5.8)
|
0.0
|
0.972
|
24,250 (2.2)
|
47,283 (2.7)
|
+ 0.5
|
< 0.001
|
|
Diabetes
|
79 (8.6)
|
231 (17.4)
|
+ 8.8
|
< 0.001
|
60,930 (5.4)
|
155,718 (8.9)
|
+ 6.5
|
< 0.001
|
|
Depression
|
66 (7.2)
|
86 (6.5)
|
−0.7
|
0.515
|
106,405 (9.5)
|
171,204 (9.7)
|
+ 0.2
|
< 0.001
|
|
COPD
|
44 (4.8)
|
93 (7.0)
|
+ 2.2
|
0.031
|
24,696 (2.2)
|
64,071 (3.6)
|
+ 1.4
|
< 0.001
|
|
Asthma
|
92 (10.0)
|
157 (11.8)
|
+ 1.8
|
0.177
|
78,615 (7.0)
|
199,049 (11.3)
|
+4.3
|
< 0.001
|
|
Osteoarthritis
|
146 (15.9)
|
196 (14.7)
|
−1.2
|
0.468
|
123,356 (11.0)
|
157,758 (9.0)
|
−2.0
|
< 0.001
|
|
Rheumatoid arthritis
|
13 (1.4)
|
14 (1.1)
|
−0.3
|
0.442
|
10,383 (0.9)
|
18,234 (1.0)
|
+ 0.1
|
< 0.001
|
- CRC colorectal cancer, COPD chronic obstructive pulmonary disease, DVT deep vein thrombosis, IHD ischaemic heart disease, MI myocardial infarction, PE pulmonary embolism, TIA transient ischaemic attack
