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Table 7 Univariate logistic regression model of clinical parameters on treatment response in stratified high---grade serous carcinoma (HGSC)a

From: Characteristics and outcome of the COEUR Canadian validation cohort for ovarian cancer biomarkers

  All HGSC Advanced stage HGSC
Hazard 95.0% CI    Hazard 95.0% CI   
Ratio Lower Upper n p value Ratio Lower Upper n p value
BRCA mutation carrier status
 Non carrier     247 reference     228 reference
 BRCA1 carrier 0.29 0.11 0.77 38 0.013 0.34 0.13 0.91 32 0.031
 BRCA2 carrier 0.72 0.27 1.89 22 0.499 0.73 0.27 1.94 21 0.524
 All mutated vs no mutation 0.44 0.22 0.89 307 0.022 0.49 0.24 1.00 281 0.042
Provinces
 Quebec     256 reference     239 reference
 Ontario 0.47 0.27 0.82 93 0.008 0.40 0.21 0.74 80 0.00
 Alberta 0.22 0.08 0.58 46 0.002 0.19 0.07 0.55 40 0.002
 Manitoba NA NA NA 8 0.999 NA NA NA 5 NA
 British Columbia 0.95 0.63 1.44 160 0.808 0.92 0.60 1.40 155 0.689
  1. Bold values highlights the statistically significant difference with the reference category
  2. a platinum-­-based patients only