A study on volatile organic compounds emitted by in-vitro lung cancer cultured cells using gas sensor array and SPME-GCMS

Table 14 The potential lung cancer biomarkers detected in this study were compared to the in-vitro and in vivo results of previous studies which were found in Scopus database

Class Specific compounds (In this study)		Origin	Comparison with Literature
Class Specific compounds (In this study)		Origin	Cell lines	^aTissues	Breath	References
Alkanes Straight chain	Dodecane Heneicosane	Endogenous- lipid peroxidation by reactive oxygen species (ROS) s	✓	✓	✓✓	[28, 29, 72, 76, 78,79,80]
			-	✓	✓	[29, 74, 80]
			-	-	✓	[28, 72, 73]
Aldehydes	Decanal	Endogenous- peroxidation of omega3 and omega6 fatty acids (PUFAs), components of cell membrane phospholipids	✓	✓	-	[33, 80, 82, 86]
Aldehydes	Nonanal		✓	✓	-	[33, 80, 82, 86]
Alcohol	2-Ethyldodecanol	Endogenous- Hydroxylation of the lipid peroxidation biomarkers via cytochrome p450 enzymes	-	-	-	[80]

ISSN: 1471-2407