BMC Cancer

Table 4 Univariate analyses of the association of HLTF expression with overall survival and disease-free survival

From: Helicase-like transcription factor expression is associated with a poor prognosis in Non-Small-Cell Lung Cancer (NSCLC)

Outcome			Overall survival (OS)				Disease-free survival (DFS)
Category		n	Estimate at 5 years	Logrank p-value	HR (95% CI)^a	Wald p-value	Estimate at 5 years	Logrank p-value	HR (95% CI)^a	Wald p-value
WT	<=20.6	86	61%	0.63	1.03 (0.97–1.1)	0.34	48%	0.14	1.01 (0.95–1.08)	0.72
WT	> 20.6	85	64%	0.63	1.03 (0.97–1.1)	0.34	61%	0.14	1.01 (0.95–1.08)	0.72
I21R	<=2.23	83	63%	0.65	1.03 (0.92–1.15)	0.61	58%	0.73	1.02 (0.93–1.13)	0.64
I21R	> 2.23	88	61%	0.65	1.03 (0.92–1.15)	0.61	49%	0.73	1.02 (0.93–1.13)	0.64
Composite covariable	Wt > 20.6 or Mut < =2.23	146	65%	0.47	1.26 (0.67–2.34)	0.48	59%	0.0096	1.96 (1.17–3.3)	0.011
Composite covariable	Wt < =20.6 and Mut > 2.23	25	50%	0.47	1.26 (0.67–2.34)	0.48	25%	0.0096	1.96 (1.17–3.3)	0.011

Cox proportional hazard regression model and log-rank test were used. A cut-off of p ≤ 0.05 was used for statistical significance
^aNote: HRs for WT HLTF represent the increase of the hazard for 10 units increase in the WT HLTF

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