Significant association between ERCC2 and MTHR polymorphisms and breast cancer susceptibility in Moroccan population: genotype and haplotype analysis in a case-control study

Table 4 Association of ERCC2 and MTHFR haplotypes and risk of breast cancer

Haplotype	Cases (n = 302)	Controls (n = 312)	OR (95% CI)^a	p ^b
rs1799793-rs13181 (ERCC2)	n (%)
G-A	151 (50)	161 (51.5)	1	0.38
A-A	59 (19.5)	73 (23.5)	0.856 (0.56–1.31)	0.52
A-C	41 (13.6)	12 (3.8)	3.71 (1.7–8.12)	0.0002
G-C	51 (16.9)	66 (21.2)	0.82 (0.52–1.28)	0.42
D’	0.17	0.45
r²	0.03	0.02
rs1801133-rs1801131 (MTHFR)	n (%)
C-A	146 (48.3)	164 (52.5)	1	0.26
T-A	79 (26.2)	68 (21.9)	1.3 (0.84–2.03)	0.17
T-C	23 (7.5)	19 (6)	1.36 (0.63–2.96)	0.39
C-C	54 (18)	61 (19.6)	0.99 (0.61–1.62)	0.59
D’	0.12	0.16
r²	0.003	0.003

N (%): number and % of haplotypes
^aOR (Odds ratio) and 95% CI (confidence interval)
^bbold values are statistically significant (p < 0.05), D’ Lewontin’s standardized disequilibrium coefficient, r² squared correlation coefficient

ISSN: 1471-2407