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Table 4 Association of ERCC2 and MTHFR haplotypes and risk of breast cancer

From: Significant association between ERCC2 and MTHR polymorphisms and breast cancer susceptibility in Moroccan population: genotype and haplotype analysis in a case-control study

Haplotype Cases (n = 302) Controls (n = 312) OR (95% CI)a p b
rs1799793-rs13181
(ERCC2)
n (%)   
 G-A 151 (50) 161 (51.5) 1 0.38
 A-A 59 (19.5) 73 (23.5) 0.856 (0.56–1.31) 0.52
A-C 41 (13.6) 12 (3.8) 3.71 (1.7–8.12) 0.0002
 G-C 51 (16.9) 66 (21.2) 0.82 (0.52–1.28) 0.42
D’ 0.17 0.45   
r2 0.03 0.02   
rs1801133-rs1801131
(MTHFR)
n (%)   
 C-A 146 (48.3) 164 (52.5) 1 0.26
 T-A 79 (26.2) 68 (21.9) 1.3 (0.84–2.03) 0.17
 T-C 23 (7.5) 19 (6) 1.36 (0.63–2.96) 0.39
 C-C 54 (18) 61 (19.6) 0.99 (0.61–1.62) 0.59
D’ 0.12 0.16   
r2 0.003 0.003   
  1. N (%): number and % of haplotypes
  2. aOR (Odds ratio) and 95% CI (confidence interval)
  3. bbold values are statistically significant (p < 0.05), D’ Lewontin’s standardized disequilibrium coefficient, r2 squared correlation coefficient
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