Skip to main content

Table 2 Genotype and allele distribution of ERCC2 and MTHFR polymorphisms in breast cancer cases and controls

From: Significant association between ERCC2 and MTHR polymorphisms and breast cancer susceptibility in Moroccan population: genotype and haplotype analysis in a case-control study

SNP (gene) Genotype Cases (n, %) Controls (n, %) OR (95% CI)a p b
rs1799793 (ERCC2)
 Codominant G/G 76 (50.3) 81 (51.9) 1  
  Heterozygote G/A 50 (33.1) 65 (41.7) 0.82 (0.51–1.33) 0.42
  Homozygote A/A 25 (16.6) 10 (6.4) 2.66 (1.20–5.91) 0.016
 Dominant G/G 76 (50.3) 81 (51.9) 1 0.78
G/A-A/A 75 (49.7) 75 (48.1) 1.07 (0.68–1.67)
 Recessive G/G-G/A 126 (83.4) 146 (93.6) 1 0.0069
A/A 25 (16.6) 10 (6.4) 2.90 (1.34–6.26)
 Overdominant G/G-A/A 101 (66.9) 91 (58.3) 1 0.12
G/A 50 (33.1) 65 (41.7) 0.69 (0.44–1.10)
 Log-additive 1.29 (0.93–1.79) 0.13
 Allele G 202 (67) 227 (73) 1 0.11
A 100 (33) 85 (27) 1.32 (0.94–1.87)
 HWE   p = 0.002 p = 0.52   
rs13181 (ERCC2)
 Codominant A/A 80 (53) 91 (58.3) 1  
  Heterozygote C/A 50 (33.1) 52 (33.3) 1.09 (0.67–1.79) 0.72
  Homozygote C/C 21 (13.9) 13 (8.3) 1.84 (0.86–3.91) 0.11
 Dominant A/A 80 (53) 91 (58.3) 1 0.34
C/A-C/C 71 (47) 65 (41.7) 1.24 (0.79–1.95)
 Recessive A/A-C/A 130 (86.1) 143 (91.7) 1 0.12
C/C 21 (13.9) 13 (8.3) 1.78 (0.86–3.69)
 Overdominant A/A-C/C 101 (66.9) 104 (66.7) 1 0.97
C/A 50 (33.1) 52 (33.3) 0.99 (0.62–1.59)
 Log-additive 1.26 (0.91–1.76) 0.16
 Allele A 210 (70) 234 (75) 1 0.13
C 92 (30) 78 (25) 1.31 (0.92–1.87)
 HWE   p = 0.007 p = 0.16   
rs1801133 (MTHFR)
 Codominant C/C 73 (48.3) 80 (51.3) 1  
  Heterozygote T/C 54 (35.8) 65 (41.7) 0.91 (0.56–1.47) 0.70
  Homozygote T/T 24 (15.9) 11 (7) 2.39 (1.09–5.22) 0.028
 Dominant C/C 73 (48.3) 80 (51.3) 1 0.6
T/C-T/T 78 (51.7) 76 (48.7) 1.12 (0.72–1.76)
 Recessive C/C-T/C 127 (84.1) 145 (93) 1 0.017
T/T 24 (15.9) 11 (7) 2.49 (1.17–5.29)
 Overdominant C/C-T/T 97 (64.2) 91 (58.3) 1 0.29
T/C 54 (35.8) 65 (41.7) 0.78 (0.49–1.24)
 Log-additive 1.29 (0.93–1.80) 0.13
 Allele C 200 (66) 225 (72)   0.11
T 102 (34) 87 (28) 0.76 (0.54–1.07)
 HWE   p = 0.013 p = 0.65   
rs1801131 (MTHFR)
 Codominant A/A 83 (55) 86 (55.1) 1  
  Heterozygote C/A 59 (39.1) 60 (38.5) 1.02 (0.64–1.63) 0.94
  Homozygote C/C 9 (6) 10 (6.4) 0.93 (0.36–2.41) 0.88
 Dominant A/A 83 (55) 86 (55.1) 1 0.98
C/A-C/C 68 (45) 70 (44.9) 1.01 (0.64–1.58)
 Recessive A/A-C/A 142 (94) 146 (93.6) 1 0.87
C/C 9 (6) 10 (6.4) 0.93 (0.37–2.34)
 Overdominant A/A-C/C 92 (60.9) 96 (61.5) 1 0.91
C/A 59 (39.1) 60 (38.5) 1.03 (0.65–1.62)
 Log-additive 0.99 (0.69–1.43) 0.97
 Allele A 225 (75) 232 (74) 1 0.97
C 77 (25) 80 (26) 0.99 (0.69–1.42)
 HWE   p = 0.72 p = 0.91   
  1. n, % number and % of individuals
  2. aOR (Odds ratio) and 95% CI (confidence interval)
  3. bbold values are statistically significant (P < 0.05), HWE Hardy-Weinberg equilibrium
\