Specifications of analyzed patients N = 99 | PFS-HR (95% CI) | p | OS-HR (95% CI) | p |
Age | 1.012 (0.987–1.038) | 0.351 | 1.007 (0.981–1.035) | 0.590 |
Number of metastatic organs | 1.083 (0.891–1.317) | 0.423 | 1.100 (0.896–1.350) | 0.364 |
PFS-HR (95% CI) | p | OS-HR (95% CI) | p | |
Gender | ||||
man/ woman | 1 / 1.367 (0.807–2.316) | 0.245 | 1 / 1.388 (0.792–2.435) | 0.252 |
MSKCC score | ||||
0 / 1 / 2 | 1 / 3.770 (1.345–28.435) / 6.693 (1.813–49.061) | 0.019 | 1 / 2.692 (1.355–20.445) / 5.199 (1.713–37.929) | 0.023 |
Dose reduction | ||||
Yes / No | 1 / 1.492 (0.947–2.506) | 0.065 | 1 / 1.553 (0.963–2.504) | 0.071 |
Nephrectomy | ||||
Yes / No | 1 / 2.702 (1.508–4.840) | 0.001 | 1 / 3.189 (1.741–5.842) | < 0.001 |
Dose escalation | ||||
Yes / No | 1 / 2.665 (1.486–4.780) | 0.001 | 1 / 3.157 (1.613–6.179) | 0.001 |
Dose scheme modification | ||||
Yes / No | 1 / 2.569 (1.437–4.595) | 0.001 | 1 / 2.444 (1.288–4.636) | 0.006 |
Therapeutic lines after sunitinib | ||||
2 / 1 / 0 | NA | NA | 1 / 7.731 (2.318–25.787) / 4.043 (1.228–13.311) | 0.001 |