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Table 4 Relationship among reproductive factors and breast cancer stratified by the genetic score; odds ratios adjusted for propensity score, menopausal status and the remaining variables in the table

From: Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project

Variable Category Genetic score OR (95% CI)
Number of deliveries 0 Any value 1 (reference)
1–2 0 0.06 (0.01–0.72)
  1 0.27 (0.12–0.62)
  2 0.82 (0.43–1.59)
  3 0.94 (0.35–2.53)
  4 2.64 (0.09–76.7)
> 2 0 0.10 (0.01–1.18)
  1 0.24 (0.10–0.58)
  2 0.43 (0.21–0.88)
  3 0.83 (0.29–2.38)
  4 2.90 (0.07–118)
Age at menopause < 50 years 0 0.93 (0.18–4.69)
  1 0.51 (0.33–0.79)
  2 0.87 (0.62–1.22)
  3 0.95 (0.58–1.55)
  4 1.13 (0.17–7.41)
≥ 50 years Any value 1 (reference)
  1. Genetic score obtained adding 1 point each if: rs2229712 C allele is present, rs1269851 C allele is present, rs35652107 A allele is absent, rs6018027 C allele is absent