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Table 4 Relationship among reproductive factors and breast cancer stratified by the genetic score; odds ratios adjusted for propensity score, menopausal status and the remaining variables in the table

From: Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project

Variable

Category

Genetic score

OR (95% CI)

Number of deliveries

0

Any value

1 (reference)

1–2

0

0.06 (0.01–0.72)

 

1

0.27 (0.12–0.62)

 

2

0.82 (0.43–1.59)

 

3

0.94 (0.35–2.53)

 

4

2.64 (0.09–76.7)

> 2

0

0.10 (0.01–1.18)

 

1

0.24 (0.10–0.58)

 

2

0.43 (0.21–0.88)

 

3

0.83 (0.29–2.38)

 

4

2.90 (0.07–118)

Age at menopause

< 50 years

0

0.93 (0.18–4.69)

 

1

0.51 (0.33–0.79)

 

2

0.87 (0.62–1.22)

 

3

0.95 (0.58–1.55)

 

4

1.13 (0.17–7.41)

≥ 50 years

Any value

1 (reference)

  1. Genetic score obtained adding 1 point each if: rs2229712 C allele is present, rs1269851 C allele is present, rs35652107 A allele is absent, rs6018027 C allele is absent