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Fig. 2 | BMC Cancer

Fig. 2

From: AKT1 restricts the invasive capacity of head and neck carcinoma cells harboring a constitutively active PI3 kinase activity

Fig. 2

AKT1 inhibition increases CAL33 cell migration in a 3D assay. a Spheroids generated with CAL33 cells expressing a control shRNA (shCont), a shRNA sequence targeting AKT1 (shAKT1) or control cells treated with the pan-AKT inhibitor MK-2206 (shCont+MK) were embedded in an extracellular matrix. Pictures of the spheroids were acquired at day 0 and day 8 for analysis. b Spheroid surface area was measured after 8 days. Error bars represent the data mean +/− SEM from at least three independent experiments; one-way ANOVA with Bonferroni’s post-test: *** p < 0.001 as compared to shCont

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BMC Cancer

ISSN: 1471-2407

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