Table 3 Characteristics of included studies- colorectal cancer
From: Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies
Study source | Sex | Study period | Source of subjects | No of case | No of control/cohort size | Cancer site | Exposure assessment | Exposure Definition | Adjustment for covariates | Study quality |
|---|---|---|---|---|---|---|---|---|---|---|
Case-control studies | ||||||||||
Iqbal U [47], 2017, China | M/F | 2001–2011 | The Taiwan NHI database | 86,597 | 346,388 | Colorectal cancer | Prescription | Patients had aspirin prescribed at least for 2 months during the 3-year period before the initial cancer diagnosis | 1,2,13,14,15,16,17 | 7 |
Friis S [70], 2015, Dermark | M/F | 1994–2011 | Danish Cancer Registry, Aarhus University Prescription Database, Danish National Patient Registry, Danish Civil Registration System | 10,280 | 10,280 | Colorectal cancer | Prescription database | Have 2 or more prescriptions for aspirin(ever use) | 1,2,14,26,27,28,29,30,31,32,33. | 8 |
Rennert G [71], 2010, Israel | M/F | 1988–2006 | The MECC | 2648 | 2566 | Colorectal cancer | Interviewed | Daily aspirin use for at least 3 years | 1,2,7,26 | 5 |
Din FV [72], 2010, UK | M/F | 2001–2008 | SCCS | 2279 | 2907 | Colorectal cancer | Questionnaire | Use > 4 tablets/week for > 1 month | 1,2,3,6,8,18,19,34,35 | 4 |
Harris RE [73], 2008, US | M/F | 2003–2004 | The CHRI | 326 | 652 | Colon cancer | Questionnaire | Use at least once per week for more than 1 year | 1,3,4,6,7,8,26,36 | 5 |
Kim S [74], 2008, US | M/F | 2001–2006 | North Carolina Colon Cancer Study II | 1057 | 1019 | Colorectal cancer | Questionnaire | Any use of aspirin in the past 5 years (ever users) | 1,2,7, 8,18,37, 38,39,40 | 6 |
Hoffmeister M [75], 2007, Germany | M/F | 2003–2004 | The Rhine–Neckar–Odenwald region in the South-West of Germany | 477 | 517 | Colorectal cancer | Questionnaire | Use at least 2 times per week for at least 1 year(current regular use) | 1,2,3,4,5,6,8,22,27,30,41,42,43 | 8 |
Slattery ML [76], 2006, US | M/F | 1991–1994 | KPMCP | 2351 | 2972 | Colorectal cancer | Questionnaire | Use at least three times a week for 1 month(regular) | 1,2,7 | 7 |
Macarthur M [77], 2005, UK | M/F | 1998–2000 | Grampian Health Board residents | 264 | 408 | Colorectal cancer | Questionnaire | Use aspirin every day for a month or more(regular) | 1,2 | 6 |
Juarranz M [78], 2002, Spain | M/F | 1995–1996 | The Research Unit of the Council of Health and Social Services of the Community ofMadrid | 196 | 228 | Colon cancer | Questionnaire | Consider aspirin use as a continuous numeric variable in milligrams/week -not further defined | 1,2 | 8 |
Evans RC [79], 2002, UK | M/F | – | Merseyside and Cheshire Cancer Registry | 512 | 512 | Colorectal cancer | Questionnaire | Use at least once per day(regular) | 1,2,26,38 | 8 |
Neugut AI [80], 1998, US | M/F | 1989–1992 | Columbia-Prebyterian Medical Center | 256 | 322 | Colon cancer | Medical record | Use aspirin-not further defined | 1,4,5 | 6 |
Rosenberg L [81], 1998, US | M/F | 1992–1994 | Hospital in Massachusetts | 942 | 935 | Large bowel carcinoma | Questionnaire | Use at least 4 days a week for at least 3 months | 1,2 | 9 |
La VC [82], 1997, Italy | M/F | 1992–1996 | Population from Italian areas | 1357 | 1891 | Colorectal adenoma | Questionnaire | Use more than four times per week for > 6 months | 1,2,5,6,8,18,26,34, 43 | 7 |
Reeves MJ [83], 1996, US | F | 1991–1992 | Wisconsin Cancer Reporting system | 21 | 22 | Colorectal cancer | Self-reported | Use at least one table twice weekly or more than at least 12 months | 1,4,8,30 | 8 |
Suh O [84], 1993, US | M/F | 1982–1991 | Roswell Park Tumor Registry and Diagnostic Index | 830 | 1662 | Colorectal adenoma | Questionnaire | Use aspirins for at least 1 year(users) | 1,2,5,26 | 9 |
Kune GA [85], 1988, Australia | M/F | 1980–1981 | Population in Melbourne | 715 | 727 | Colorectal adenoma | Questionnaire, hospital records, and interview | Use aspirin “daily” “weekly” or “don’t know- not further defined” | 1,2 | 8 |
Cohort studies | ||||||||||
Park SY [86], 2017, US | M/F | 1993–2012 | The MEC Study | 3879 | 183,199 | Colorectal cancer | Questionnaire | Had ever use of aspirin | 1,3,4,6,8,18,19,27,30,34,37,43, 48,49 | 8 |
Kim C [87], 2016, US | M | 1982–2000 | Physicians Health Study | 268 | 446 | Colorectal cancer | Questionnaire | Use of aspirin- not further defined | 6,8,18,19, 20 | 9 |
Soriano LC [88], 2016, UK(STUDY 1) | M/F | 2000–2011 | THIN | 3033 | 10,000 | Colorectal cancer | Prescription | No recorded use at any time(non user) | 1,2,3,8,21, 22,24,25 | 9 |
Soriano LC [88], 2016, UK(STUDY 2) | M/F | 2001–2012 | THIN | 3174 | 10,000 | Colorectal cancer | Prescription | No recorded use at any time(non user) | 1,2,3,8,21,22,23 | 9 |
Soriano LC [88], 2016, UK(STUDY 3) | M/F | 2001–2012 | THIN | 12,333 | 20,000 | Colorectal cancer | Prescription | No recorded use at any time(non user) | 1,2,3,8,21,22 | 9 |
Vaughan LE [89], 2016, US | F | 2004–2011 | IWHS | 218 | 14,386 | Colon cancer | Questionnaire | Never use aspirin (non-user) | 1,3,8,22 | 8 |
Cao Y [8], 2016, US | M/F | 1980–2010 1986–2012 | NHS and HPFS | 2895 | 135,965 | Colorectal cancer | Questionnaire | Use at least 2 times per week(regular) | 3,4,6,7,8,18,19,27,30,34,37,42,43,49,50,51,52,53 | 9 |
Lin CC [90], 2015, Chinaa | M/F | 2000–2009 | The Longitudinal Health Insurance Database | 467 | 60,828 | Colorectal cancer | Prescription database | Use any low-dose aspirin (75–165 mg) | 1,2,54,55 | 8 |
Hollestein LM [91], 2014, Netherlandsa | M/F | 1998–2010 | PHARMO and the Eindhoven Cancer Registry | 972 | 109,276 | Colorectal cancer | Prescription database | Low dose aspirin (≤100 mg daily)- not further defined | 1,2,56,72 | 8 |
Brasky TM [92], 2014, US | F | 1998–2010 | WHI | 1397 | 140,933 | Colorectal cancer | Self-administered questionnaires | Use at both baseline and year 3 visits (consistent) | 1,3,4,5,6,7,8,37,18,19,22,26,27,33,43,50,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71 | 9 |
Brasky TM [93], 2012, US | M/F | 2002–2008.12.30 | The VITAL | 451 | 64,847 | Colorectal cancer | Questionnaire | Use ≥1 day/week for ≥ 1 year(regular) | 1,3,4,5,6,7,8,9,10,18,19,22,28,30,33,42,43, 50,67,68,69,71 | 8 |
Ruder EH [94], 2011, US | M/F | 1996–2006 | National Institutes of Health-AARP Diet and Health Study | 3894 | 301,240 | Colorectal cancer | Self-administered questionnaire | Use aspirin during the previous 12 months | 1,2,3,4,5, 6,7,8,18,27 | 7 |
Friis S [95], 2009, Denmark | M/F | 1995–2006 | Danish Diet, Cancer, and Health Study | 615 | 51,053 | Colorectal cancer | Questionnaire | Use fewer than 2 pills per month (nonuse) | 1,2,6,8,14,22,27,30, | 7 |
Siemes C [96], 2008, Netherlands | M/F | 1992–2004 | The Rotterdam Study | 195 | 7621 | Colorectal cancer | Questionnaire and prescriptions | The absence of a prescription for any non-aspirin or aspirin NSAID(no use) | 1,2,3,8,18, 27,34,70,73,74 | 8 |
Vinogradova Y [97], 2007, UKa | M/F | 1995–2005 | QRESEARCH database | 1226 | 5369 | Colorectal cancer | Prescription database | Receive ≥1 prescription for aspirin in the 13 to 48 months before index date | 3, 8,22,41 | 8 |
Jacobs EJ [98], 2007, US | M/F | 1992–2003 | Cancer Prevention Study II Nutrition Cohort | 1861 | 146,113 | Colorectal cancer | Questionnaire | Use at least 30 “times” per month(daily use of adult-strength) | 1,2,3,5,7,18,22,27,28,30,36,68,52,53 | 8 |
Larsson SC [99], 2006, Sweden | M/F | 1998–2005 | Swedish Mammography Cohort and Cohort of Swedish Men | 705 | 74,250 | Colorectal cancer | Questionnaire | Aspirin use- not further defined | 1,2,3,4,5,8,18 28 | 9 |
Muscat JE [100], 2005, US | M/F | 1983–1999 | The Framingham Heart study | 145 | 433 | Colorectal cancer | Questionnaire | Never/< 1/week, 1–3/week, > 3/week | 1,2,3,44 | 9 |
Rahme E [101], 2003, Canada | M/F | 1997–2001 | RAMQ | 179 | 2568 | Colorectal adenoma | Prescription | Use at least 1 year | 45,46,47 | 7 |
Rodríguez LAG [102], 2001, UKa | M/F | 1994–1997 | The GPRD | 2002 | 943,903 | Colorectal cancer | Prescription database | Never received a single prescription(non-user) | 1,2 | 8 |
Schreinemachers DM [63], 1994, US | M/F | 1971–1987 | The National Health and Examination Survey Ι | 169 | 12,668 | Colorectal cancer | Self reported | Use aspirin during the 30-day period before the interview | 1,2 | 6 |
Paganini-Hill A [103], 1989, US | M/F | 1981–1988 | Population from Leisure World, Laguna Hills, US | 181 | 13,870 | Colon cancer | Questionnaire | Aspirin use: none,<daily, daily | 2 | 4 |