Table 2 Characteristics of included studies- esophagus cancer
From: Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies
Study source | Sex | Study period | Source of subjects | No of case | No of control/cohort size | Cancer site | Exposure assessment | Exposure Definition | Adjustment for covariates | Study quality |
|---|---|---|---|---|---|---|---|---|---|---|
Case-control studies | ||||||||||
 Figueroa JD [51], 2009, US | M/F | 1993–1995 | Population from Connecticut, New Jersey, and western Washington state | 282 | 695 | Oesophageal cancer | Structured interviews | Use at least once per week for 6 months or more | 1,2,3,10,11,12 | 7 |
 Sadeghi S [64], 2008, Australia | M/F | 2001–2005 | Population from Australia | 1102 | 1580 | Oesophageal cancer | Questionnaire | Use at least once a week for duration of 6 months or more(regular) | 1,2,4,6,10,16,28,29 | 6 |
 Duan L [52], 2008, US | M/F | 1992–1997 | Los Angeles County Cencer Surveillance Program | 220 | 1356 | Esophageal adenocarcinoma | Structured questionnaire | Use of aspirin - not further defined | 1,2,3,5,10,11,14,15,16, | 7 |
 Fortuny J [53], 2007, US | M/F | 1980–2002 1993–2004 | GHC and HFHS | 277 | 3996 | Oesophageal cancer | Outpatient pharmacy records | No prescription for aspirin (never users) | 1,2,11,17,18 | 7 |
 Ranka S [65], 2006, UK | M/F | 1999–2004 | Population from Norfolk | 411 | 1644 | Oesophageal cancer | Self-reported,medical admission notes and nursing records | Use of aspirin - not further defined | 3,6 | 8 |
 Anderson LA [66], 2006, Ireland | M/F | 2002–2004 | The FINBAR study | 224 | 260 | Esophageal adenocarcinoma | Interview | Use aspirin at least once weekly for ≥ 6 months | 1,2,3,5, 6,10,30,31, | 6 |
 Jayaprakash V [67], 2006, US | M/F | 1982–1998 | RPCI | 163 | 482 | Oesophageal cancer | Questionnaire | Use at least once a week for 6 months (regular) | 1,2,3,6,10,32, | 6 |
 Sharp L [68], 2001, UK | F | 1993–1996 | Population in England and Scotland | 159 | 159 | Oesophagus squamous cell carcinoma | Interview | Daily use of aspirin for at least a month | 1,33 | 7 |
Cohort sutdies | ||||||||||
 Macfarlane TV [69], 2014, UKa | M/F | 1996–2010 | PCCIU database | 1197 | 3585 | Oesophageal cancer | Prescription database | Had at least one Prescription (users) | 1,2,13,23,24,25,26,27 | 7 |
 Abnet CC [59], 2009, US | M/F | 1995–2003 | AARP | 228 | 311,115 | Oesophageal adenocarcinoma | Questionnaire | Any use in the past 12 months | 1,2,3,5,6,10,20,21,22 | 7 |
 Lindblad M [61], 2005, UKa | M/F | 1994–2001 | GPRD database | 909 | 1000 | Esophageal cancer | Prescription database | Any recorded use of aspirin (ever use) | 1,2,3,6, 10,14, 19 | 8 |
 Friis S [62], 2003, Denmarka | M/F | 1989–1997 | Population of North Jutland County | 26 | 29,470 | Oesophagus cancer | Prescription database | 75–150 mg once daily (low-dose aspirin) | 1,2 | 8 |