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Table 2 Characteristics of included studies- esophagus cancer

From: Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies

Study source Sex Study period Source of subjects No of case No of control/cohort size Cancer site Exposure assessment Exposure Definition Adjustment for covariates Study quality
Case-control studies
 Figueroa JD [51], 2009, US M/F 1993–1995 Population from Connecticut, New Jersey, and western Washington state 282 695 Oesophageal cancer Structured interviews Use at least once per week for 6 months or more 1,2,3,10,11,12 7
 Sadeghi S [64], 2008, Australia M/F 2001–2005 Population from Australia 1102 1580 Oesophageal cancer Questionnaire Use at least once a week for duration of 6 months or more(regular) 1,2,4,6,10,16,28,29 6
 Duan L [52], 2008, US M/F 1992–1997 Los Angeles County Cencer Surveillance Program 220 1356 Esophageal adenocarcinoma Structured questionnaire Use of aspirin - not further defined 1,2,3,5,10,11,14,15,16, 7
 Fortuny J [53], 2007, US M/F 1980–2002 1993–2004 GHC and HFHS 277 3996 Oesophageal cancer Outpatient pharmacy records No prescription for aspirin (never users) 1,2,11,17,18 7
 Ranka S [65], 2006, UK M/F 1999–2004 Population from Norfolk 411 1644 Oesophageal cancer Self-reported,medical admission notes and nursing records Use of aspirin - not further defined 3,6 8
 Anderson LA [66], 2006, Ireland M/F 2002–2004 The FINBAR study 224 260 Esophageal adenocarcinoma Interview Use aspirin at least once weekly for ≥ 6 months 1,2,3,5, 6,10,30,31, 6
 Jayaprakash V [67], 2006, US M/F 1982–1998 RPCI 163 482 Oesophageal cancer Questionnaire Use at least once a week for 6 months (regular) 1,2,3,6,10,32, 6
 Sharp L [68], 2001, UK F 1993–1996 Population in England and Scotland 159 159 Oesophagus squamous cell carcinoma Interview Daily use of aspirin for at least a month 1,33 7
Cohort sutdies
 Macfarlane TV [69], 2014, UKa M/F 1996–2010 PCCIU database 1197 3585 Oesophageal cancer Prescription database Had at least one Prescription (users) 1,2,13,23,24,25,26,27 7
 Abnet CC [59], 2009, US M/F 1995–2003 AARP 228 311,115 Oesophageal adenocarcinoma Questionnaire Any use in the past 12 months 1,2,3,5,6,10,20,21,22 7
 Lindblad M [61], 2005, UKa M/F 1994–2001 GPRD database 909 1000 Esophageal cancer Prescription database Any recorded use of aspirin (ever use) 1,2,3,6, 10,14, 19 8
 Friis S [62], 2003, Denmarka M/F 1989–1997 Population of North Jutland County 26 29,470 Oesophagus cancer Prescription database 75–150 mg once daily (low-dose aspirin) 1,2 8
  1. 1 = age, 2 = sex, 3 = smoking, 4 = family history, 5 = educational level, 6 = alcohol intake, 7 = marriage, 8 = Fat distribution, 9 = social status, 10 = BMI, 11 = race 12 = gastroesopageal refiux disease, 13 = other NSAID 14 = upper gastrointestinal tract history, 15 = antacid use, 16 = birthplace,17 = health plan, 18 = duration of continuous enrollment in the health plan at the date of diagnosis, 19 = calendar year, 20 = total calorie, fibre and calcium intake, 21 = fruit, vegetable and/or vitamin intake, 22 = physical activity, 23 = CHD, 24 = stroke, 25 = COX-2 inhibitors, 26 = duration of observation in the database, 27 = deprivation, 28 = household income, 29 = cumulative and frequency of gastroesophageal reflux symptoms 10 y before diagnosis, 30 = location, 31 = job type, 32 = year of completing the questionnaire, 33 = general practice
  2. AARP AARP diet and health study, FINBAR the factors influencing the Barrett’s adenocarcinoma relationship study, GHC Group Health Cooperative, GPRD General Practitioners research database, HFHS Henry Ford health system’s health alliance plan, PCCIU primary care clinical informatics unit database, RPCI the Roswell park cancer Institute
  3. aStudy deemed to be prone to immortal time bias