Table 16 Characteristics of included studies- head and neck cancers
From: Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies
Study source | Sex | Study period | Source of subjects | No of case | No of control/cohort size | Cancer site | Exposure assessment | Exposure Definition | Adjustment for covariates | Study quality |
|---|---|---|---|---|---|---|---|---|---|---|
Case-control studies | ||||||||||
 Di Maso M [226], 2015, Italy | M/F | 1992–2008 | Population from Aviano, Pordenone and the greater Milan area in northern Italy | 198 | 596 | Nasopharyngeal cancer | Questionnaire | Use at least one aspirin a week for at least 6 months(regular) | 1,2,3,5,11,12,13 | 6 |
 Becker C [227], 2015, UK | M/F | 1995–2013 | CPRD | 2745 | 16,470 | Head and neck cancer | Prescription database | Use aspirin ≥1 Prescription | 3,6,8,10 | 7 |
 Macfarlane TV [228], 2012, Europe | M/F |  | ARCAGE | 1779 | 1993 | Head and neck cancer | Questionnaire | Use at least once a weekfor a year(regular) | 1,2,3,5,6,10,18 | 7 |
 Ahmadi N [229], 2010, US | M/F | 2003–2007 | Patients from the Lombardi Comprehensive Cancer Center, at GUMC | 25 | 25 | Head and neck cancer | Questionnaire | Daily use of aspirin | 5,19 | 5 |
 Jayaprakash V [230], 2006, US | M/F | 1982–1998 | RPCI | 529 | 529 | Head and neck cancer | Questionnaire | Had ever taken aspirin before the onset of the present illness | 1,2,3,6 | 7 |
 Rosenquist K [231], 2005, Sweden | M/F | 2000–2004 | Population from the Southern healthcare region of Sweden | 132 | 320 | Oral and oropharyngeal squamous cell carcinoma | Interview | Had ever taken aspirin-not further defined | 3,6 | 6 |
 Bosetti C [232], 2003, Italy | M/F | 1992–2000 | Population from Italy | 740 | 1779 | Oral and pharyngeal, laryngeal cancer | Questionnaire | Use at least once a week for more than 6 months | 1,2,3,5,6,11 | 6 |
Cohort studies | ||||||||||
 Macfarlane TV [69], 2014, UKa | M/F | 1996–2010 | PCCIU database | 1195 | 3580 | Head and neck cancer | Prescription database | Had at least one Prescription (users) | 1,2,8,14,15,16,17 | 7 |
 Wilson JC [233], 2013, US | M/F | 1993–2001 | PLCO | 316 | 142,034 | Head and neck cancer | Questionnaire | Use aspirin regularly -not further defined | 1,2,3,10 | 7 |
 Friis S [62], 2003, Denmarka | M/F | 1989–1997 | Population from North Jutland County | 68 | 29,470 | Head and neck cancer | Prescription database | 75–150 mg once daily(low-dose aspirin) | 1,2 | 8 |