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Table 16 Characteristics of included studies- head and neck cancers

From: Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies

Study source Sex Study period Source of subjects No of case No of control/cohort size Cancer site Exposure assessment Exposure Definition Adjustment for covariates Study quality
Case-control studies
 Di Maso M [226], 2015, Italy M/F 1992–2008 Population from Aviano, Pordenone and the greater Milan area in northern Italy 198 596 Nasopharyngeal cancer Questionnaire Use at least one aspirin a week for at least 6 months(regular) 1,2,3,5,11,12,13 6
 Becker C [227], 2015, UK M/F 1995–2013 CPRD 2745 16,470 Head and neck cancer Prescription database Use aspirin ≥1 Prescription 3,6,8,10 7
 Macfarlane TV [228], 2012, Europe M/F   ARCAGE 1779 1993 Head and neck cancer Questionnaire Use at least once a weekfor a year(regular) 1,2,3,5,6,10,18 7
 Ahmadi N [229], 2010, US M/F 2003–2007 Patients from the Lombardi Comprehensive Cancer Center, at GUMC 25 25 Head and neck cancer Questionnaire Daily use of aspirin 5,19 5
 Jayaprakash V [230], 2006, US M/F 1982–1998 RPCI 529 529 Head and neck cancer Questionnaire Had ever taken aspirin before the onset of the present illness 1,2,3,6 7
 Rosenquist K [231], 2005, Sweden M/F 2000–2004 Population from the Southern healthcare region of Sweden 132 320 Oral and oropharyngeal squamous cell carcinoma Interview Had ever taken aspirin-not further defined 3,6 6
 Bosetti C [232], 2003, Italy M/F 1992–2000 Population from Italy 740 1779 Oral and pharyngeal, laryngeal cancer Questionnaire Use at least once a week for more than 6 months 1,2,3,5,6,11 6
Cohort studies
 Macfarlane TV [69], 2014, UKa M/F 1996–2010 PCCIU database 1195 3580 Head and neck cancer Prescription database Had at least one Prescription (users) 1,2,8,14,15,16,17 7
 Wilson JC [233], 2013, US M/F 1993–2001 PLCO 316 142,034 Head and neck cancer Questionnaire Use aspirin regularly -not further defined 1,2,3,10 7
 Friis S [62], 2003, Denmarka M/F 1989–1997 Population from North Jutland County 68 29,470 Head and neck cancer Prescription database 75–150 mg once daily(low-dose aspirin) 1,2 8
  1. 1 = age, 2 = sex, 3 = smoking, 4 = family history, 5 = educational level, 6 = alcohol intake, 7 = race, 8 = other NSAIDs, 9 = social status, 10 = BMI, 11 = area of residence, 12 = period of interview, 13 = occupation, 14 = deprivation, 15 = CHD, 16 = stroke, 17 = COX-2 inhibitors, 18 = fruit consumption, 19 = marital status
  2. ARCAGE the alcohol-related cancers and genetic susceptibility, CPRD clinical practice research datalink, GUMC Georgetown University Medical School, PCCIU primary care clinical informatics unit database, PLCO prostate, lung, colorectal and ovarian cancer screening trial, RPCI the Roswell Park Cancer Institute
  3. aStudy deemed to be prone to immortal time bias