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Fig. 6 | BMC Cancer

Fig. 6

From: Compound A attenuates toll-like receptor 4-mediated paclitaxel resistance in breast cancer and melanoma through suppression of IL-8

Fig. 6

Proposed model of CpdA attenuation of PTX resistance with TLR-4-mediated IL-6, IL-8 and XIAP. TLR4 expressing BCA cells were activated by PTX during PTX administration aiming to kill cancer cells, to release pro-inflammatory cytokines IL-8 and IL-6 into the tumor microenvironment. The mechanism is a TLR-4 and NF-κB dependent pathway. TLR4 is the other target of this activated pathway. The PTX-TLR4 mediated effect can aggravate cancer progression including metastasis, PTX resistance and angiogenesis. This phenomenon can be targeted by a NF-κB specific inhibitor, CpdA, leading to the attenuation of TLR-4-mediated PTX resistance

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BMC Cancer

ISSN: 1471-2407

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