Table 5 Onset time for drug-related adverse events: diarrhea, hand-foot skin reaction, and liver dysfunction
Time of onset | Total | Child-Pugh A | Child-Pugh B | Not evaluable |
|---|---|---|---|---|
Diarrhea | 35/39 | 25/28 | 7/8 | 3/3 |
 0–30 days | 12/13 | 8/8 | 4/5 | 0/0 |
 31–60 days | 4/4 | 3/3 | 1/1 | 0/0 |
 61–90 days | 5/5 | 4/4 | 0/0 | 1/1 |
  > 90 days | 14/17 | 10/13 | 2/2 | 2/2 |
Hand-foot skin reaction | 63/64 | 51/51 | 7/8 | 5/5 |
 0–30 days | 37/38 | 29/29 | 5/6 | 3/3 |
 31–60 days | 11/12 | 9/10 | 1/1 | 1/1 |
 61–90 days | 5/5 | 5/5 | 0/0 | 0/0 |
  > 90 days | 10/9 | 8/7 | 1/1 | 1/1 |
Liver dysfunction | 0/46 | 0/30 | 0/9 | 0/7 |
 0–30 days | 0/6 | 0/2 | 0/2 | 0/2 |
 31–60 days | 0/2 | 0/1 | 0/1 | 0/0 |
 61–90 days | 0/10 | 0/8 | 0/1 | 0/1 |
  > 90 days | 0/28 | 0/19 | 0/5 | 0/4 |