Body mass index and lung cancer risk: a pooled analysis based on nested case-control studies from four cohort studies

Table 4 Adjusted odds ratio of lung cancer by smoking status according to BMI categories

BMI (kg/m²) ^a		Men and Women			Men			Women
	Cases	Controls	Adjusted OR (95% CI) ^b	Cases	Controls	Adjusted OR (95% CI) ^c	Cases	Controls	Adjusted OR (95% CI) ^c
Never Smokers
Underweight	33	161	0.83 (0.53–1.28)	15	97	0.88 (0.49–1.60)	18	64	0.84 (0.42–1.68)
Normal weight	334	1794	Reference	169	1159	Reference	165	635	Reference
Overweight	117	916	0.77 (0.59–0.99)	46	540	0.74 (0.51–1.06)	71	376	0.75 (0.51–1.11)
Obese	29	233	0.71 (0.44–1.14)	5	110	0.55 (0.22–1.40)	24	123	0.73 (0.40–1.36)
Missing	58	40	–	19	15	–	39	25	–
Former Smokers
Underweight	10	58	0.27 (0.12–0.61)	8	51	0.26 (0.11–0.61)	2	7	0.27 (0.02–3.69)
Normal weight	262	609	Reference	203	477	Reference	59	132	Reference
Overweight	272	729	0.70 (0.53–0.93)	224	599	0.66 (0.48–0.91)	55	130	0.77 (0.36–1.65)
Obese	105	297	0.55 (0.37–0.80)	83	230	0.51 (0.33–0.79)	22	67	0.67 (0.27–1.67)
Missing	38	42		26	15	–	–	27	–
Current Smokers
Underweight	207	189	1.24 (0.98–1.58)	173	162	1.26 (0.98–1.63)	34	27	0.82 (0.38–1.76)
Normal weight	1549	1860	Reference	1234	1511	Reference	315	349	Reference
Overweight	710	1085	0.79 (0.68–0.92)	537	853	0.75 (0.63–0.88)	173	232	0.87 (0.62–1.23)
Obese	237	400	0.75 (0.60–0.93)	167	286	0.72 (0.55–0.92)	70	114	0.73 (0.46–1.15)
Missing	189	22	–	127	6	–	62	16	–

^aUnderweight (BMI < 18.5), normal weight (18.5 ≤ BMI < 25), overweight (25 ≤ BMI < 30) and obese (BMI ≥ 30)
^bAdjusted for age, gender, study center, time elapsed, pack-years of smoking (except for never smokers) and education level
^cAdjusted for age, study center, time elapsed, pack-years of smoking (except for never smokers) and education level

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