Table 2 Univariate analysis of prognostic factors of overall survival
UNIVARIATE ANALYSIS | MULTIVARIATE ANALYSIS | ||||
|---|---|---|---|---|---|
Variable | N = 98 (%) | Hazard Ratio (95% CI) | P-value | Hazard Ratio (95% CI) | P-value |
Tumour size | |||||
< 7 cm | 23 (36) | 2.8 (1.6–5.0) | < 0.001 | ||
> 7 cm | 28 (44) | ||||
Number of nodules | |||||
< 2 | 77 (79) | – | NS | ||
≥ 2 | 21 (21) | ||||
AFP, ng/ml | |||||
< 400 | 83 (85) | 2.2 (1.2–4.2) | 0.01 | ||
≥ 400 | 15 (15) | ||||
Peri-tumoural Capsule (PTC) | |||||
Absent | 81 (83) | – | NS | ||
Present | 17 (17) | ||||
Ectatic Arterial Neovascularsation (EAN) | |||||
Absent | 10 (10) | 4.1 (1.0–8.0) | 0.03 | 4.1 (1.0–16.5) | 0.04 |
Present | 88 (88) | ||||
Artero-venous shunting (AVS) | |||||
Absent | 47 (48) | – | NS | ||
Present | 48 (49) | ||||
Intra-tumour necrosis (ITN) | |||||
< 50% | 89 (90) | 2.2 (1.1–4.6) | 0.02 | ||
≥ 50% | 9 (10) | ||||
Portal vein invasion (PVI) | |||||
Absent | 10 (10) | – | NS | ||
Present | 88 (88) | ||||
Child Pugh class | |||||
A | 76 (77) | – | NS | ||
B | 22 (23) | ||||
BCLC Stage | |||||
A | 10 (10) | – | NS | ||
B | 77 (78) | ||||
C | 11 (11) | ||||
Radiologic Response | |||||
CR | 15 (15) | 2.0 (1.4–2.9) | < 0.001 | 0.5 (0.3–0.8) | 0.01 |
PR | 28 (29) | ||||
SD | 36 (37) | ||||
PD | 7 (7) | ||||