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Table 2 Univariate analysis of prognostic factors of overall survival

From: Preliminary qualification of a novel, hypoxic-based radiologic signature for trans-arterial chemoembolization in hepatocellular carcinoma

UNIVARIATE ANALYSIS MULTIVARIATE ANALYSIS
Variable N = 98 (%) Hazard Ratio (95% CI) P-value Hazard Ratio (95% CI) P-value
Tumour size
 < 7 cm 23 (36) 2.8 (1.6–5.0) < 0.001   
 > 7 cm 28 (44)     
Number of nodules
 < 2 77 (79) NS   
 ≥ 2 21 (21)     
AFP, ng/ml
 < 400 83 (85) 2.2 (1.2–4.2) 0.01   
 ≥ 400 15 (15)     
Peri-tumoural Capsule (PTC)
 Absent 81 (83) NS   
 Present 17 (17)     
Ectatic Arterial Neovascularsation (EAN)
 Absent 10 (10) 4.1 (1.0–8.0) 0.03 4.1 (1.0–16.5) 0.04
 Present 88 (88)     
Artero-venous shunting (AVS)
 Absent 47 (48) NS   
 Present 48 (49)     
Intra-tumour necrosis (ITN)
 < 50% 89 (90) 2.2 (1.1–4.6) 0.02   
 ≥ 50% 9 (10)     
Portal vein invasion (PVI)
 Absent 10 (10) NS   
 Present 88 (88)     
Child Pugh class
 A 76 (77) NS   
 B 22 (23)     
BCLC Stage
 A 10 (10) NS   
 B 77 (78)     
 C 11 (11)     
Radiologic Response
 CR 15 (15) 2.0 (1.4–2.9) < 0.001 0.5 (0.3–0.8) 0.01
 PR 28 (29)     
 SD 36 (37)     
 PD 7 (7)