Skip to main content

Table 1 Image definition

From: Structural and advanced imaging in predicting MGMT promoter methylation of primary glioblastoma: a region of interest based analysis

Variable

Classification criteria

Location

 

 Type I

Tumor in which the contrast-enhancing lesion contacts both the SVZ and the cortex

 Type II

Tumor contacts the SVZ but not the cortex

 Type III

Tumor contacts the cortex but not the SVZ

 Type IV

Tumor contacts neither the SVZ nor the cortex

Tumor cross midline

 No

Tumor is limited to the unilateral cerebral hemisphere

 Yes

Tumor crosses the brain midline and extends into contralateral cerebral hemisphere

Multifocal

 No

Only one region of tumor, either enhancing or non-enhancing

 Yes

At least a region of tumor, either enhancing or non-enhancing, which is not contiguous with the major tumor mass

Necrosis

 No

No necrosis within the tumor

 Mild

Necrosis affecting ≤50% of the tumor

 Severe

Necrosis affecting > 50% of the tumor

Cyst

 No

No cyst in the tumor

 Yes

Cyst in the tumor

Edema

 No

No convincing edema

 Mild

Edema extending ≤2 cm from tumor margin

 Severe

Edema extending > 2 cm from tumor margin

Enhancement

 Nodular

Largest focal contrast-enhancement diameter of tumor ≤1.5 cm

 Patchy

Maximum contrast-enhancement diameter of tumor>1.5 cm

 Ringlike

Cystic necrosis with peripheral enhancement

Side

 Left

Tumor located in left cerebral hemisphere

 Right

Tumor located in right cerebral hemisphere

  1. Note: Location classification was based on the spatial relationship of the contrast-enhancing lesion to the subventricular zone. (SVZ = subventricular zone)