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Table 1 Image definition

From: Structural and advanced imaging in predicting MGMT promoter methylation of primary glioblastoma: a region of interest based analysis

Variable Classification criteria
Location  
 Type I Tumor in which the contrast-enhancing lesion contacts both the SVZ and the cortex
 Type II Tumor contacts the SVZ but not the cortex
 Type III Tumor contacts the cortex but not the SVZ
 Type IV Tumor contacts neither the SVZ nor the cortex
Tumor cross midline
 No Tumor is limited to the unilateral cerebral hemisphere
 Yes Tumor crosses the brain midline and extends into contralateral cerebral hemisphere
Multifocal
 No Only one region of tumor, either enhancing or non-enhancing
 Yes At least a region of tumor, either enhancing or non-enhancing, which is not contiguous with the major tumor mass
Necrosis
 No No necrosis within the tumor
 Mild Necrosis affecting ≤50% of the tumor
 Severe Necrosis affecting > 50% of the tumor
Cyst
 No No cyst in the tumor
 Yes Cyst in the tumor
Edema
 No No convincing edema
 Mild Edema extending ≤2 cm from tumor margin
 Severe Edema extending > 2 cm from tumor margin
Enhancement
 Nodular Largest focal contrast-enhancement diameter of tumor ≤1.5 cm
 Patchy Maximum contrast-enhancement diameter of tumor>1.5 cm
 Ringlike Cystic necrosis with peripheral enhancement
Side
 Left Tumor located in left cerebral hemisphere
 Right Tumor located in right cerebral hemisphere
  1. Note: Location classification was based on the spatial relationship of the contrast-enhancing lesion to the subventricular zone. (SVZ = subventricular zone)