Skip to main content

Table 2 Assessment of interaction between serum CRP concentration and folate-related SNP/factors for global methylation levels

From: Correlation between global methylation level of peripheral blood leukocytes and serum C reactive protein level modified by MTHFR polymorphism: a cross-sectional study

   

95% confidence interval

P value for trend*

P for interaction*

 

N

β*c

Lower

Upper

MTHFR (rs1801133)

     

0.046

 CT/TT

264

0.61

0.24

0.99

0.001

 

 CC

109

−0.09

−0.69

0.52

0.778

 

MTHFR (rs1801131)

     

0.735

 CC/CA

127

0.36

−0.17

0.89

0.186

 

 AA

246

0.47

0.07

0.87

0.022

 

MTR (rs1805087)

     

0.627

 GG/GA

120

0.34

−0.19

0.86

0.206

 

 AA

250

0.49

0.09

0.89

0.016

 

MTRR (rs162049)

     

0.599

 AA/AG

261

0.48

0.10

0.86

0.013

 

 GG

110

0.30

−0.30

0.89

0.328

 

MTRR (rs10380)

     

0.423

 TT/CT

79

0.66

0.02

1.30

0.043

 

 CC

292

0.37

−0.01

0.74

0.054

 

Drinking statusa

     

0.473

 Non-drinker

223

0.33

−0.08

0.74

0.118

 

 Former/Current

150

0.56

0.06

1.06

0.028

 

Folate intakeb

     

0.736

 < 340 μg/day

188

0.49

0.03

0.94

0.036

 

 ≥340 μg/day

185

0.38

−0.06

0.83

0.092

 
  1. *Adjusted by age, BMI, smoking (never, former, current), exercise (none/week, 1–2 times/week, ≥3 times/week), drinking (non-drinker, sometimes, < 150 g/week, ≥150 g/week), and folate intake (quartile)
  2. a Adjusted by age, BMI, smoking (never, former, current), exercise (none/week, 1–2 times/week, ≥3 times/week), and folate intake (quartile)
  3. b Adjusted by age, BMI, smoking (never, former, current), exercise (none/week, 1–2 times/week, ≥3 times/week), and drinking (non-drinker, sometimes, < 150 g/week, ≥150 g/week)
  4. c Average relative methylation difference per 1-category increase (included as continuous variable)