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Table 2 Assessment of interaction between serum CRP concentration and folate-related SNP/factors for global methylation levels

From: Correlation between global methylation level of peripheral blood leukocytes and serum C reactive protein level modified by MTHFR polymorphism: a cross-sectional study

    95% confidence interval P value for trend* P for interaction*
  N β*c Lower Upper
MTHFR (rs1801133)       0.046
 CT/TT 264 0.61 0.24 0.99 0.001  
 CC 109 −0.09 −0.69 0.52 0.778  
MTHFR (rs1801131)       0.735
 CC/CA 127 0.36 −0.17 0.89 0.186  
 AA 246 0.47 0.07 0.87 0.022  
MTR (rs1805087)       0.627
 GG/GA 120 0.34 −0.19 0.86 0.206  
 AA 250 0.49 0.09 0.89 0.016  
MTRR (rs162049)       0.599
 AA/AG 261 0.48 0.10 0.86 0.013  
 GG 110 0.30 −0.30 0.89 0.328  
MTRR (rs10380)       0.423
 TT/CT 79 0.66 0.02 1.30 0.043  
 CC 292 0.37 −0.01 0.74 0.054  
Drinking statusa       0.473
 Non-drinker 223 0.33 −0.08 0.74 0.118  
 Former/Current 150 0.56 0.06 1.06 0.028  
Folate intakeb       0.736
 < 340 μg/day 188 0.49 0.03 0.94 0.036  
 ≥340 μg/day 185 0.38 −0.06 0.83 0.092  
  1. *Adjusted by age, BMI, smoking (never, former, current), exercise (none/week, 1–2 times/week, ≥3 times/week), drinking (non-drinker, sometimes, < 150 g/week, ≥150 g/week), and folate intake (quartile)
  2. a Adjusted by age, BMI, smoking (never, former, current), exercise (none/week, 1–2 times/week, ≥3 times/week), and folate intake (quartile)
  3. b Adjusted by age, BMI, smoking (never, former, current), exercise (none/week, 1–2 times/week, ≥3 times/week), and drinking (non-drinker, sometimes, < 150 g/week, ≥150 g/week)
  4. c Average relative methylation difference per 1-category increase (included as continuous variable)