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Table 1 Assessment of the association between serum CRP concentration and global methylation level with and without adjustment for life-style factors using the general linear model

From: Correlation between global methylation level of peripheral blood leukocytes and serum C reactive protein level modified by MTHFR polymorphism: a cross-sectional study

     95% confidence interval   95% confidence interval  
Variable CRP (mg/dL) N Estimated mean methylation (%) Lower Upper βc Lower Upper P value for trend
Crude model 0.002–0.011 101 69.7 69.0 70.3     
  0.012–0.023 89 70.2 69.5 70.9     
  0.024–0.048 93 70.7 70.0 71.3     
  0.049–0.491 93 70.4 69.8 71.1     
       0.28 −0.02 0.58 0.071
  Log-transformed CRP      0.25 −0.07 0.56 0.123
Adjusted model 1a 0.002–0.011 100 70.1 69.0 71.2     
  0.012–0.023 89 70.7 69.6 71.9     
  0.024–0.048 92 71.4 70.3 72.6     
  0.049–0.491 92 71.3 70.1 72.5     
       0.43 0.10 0.76 0.011
  Log-transformed CRP      0.42 0.07 0.78 0.019
Adjusted model 2b 0.002–0.011 100 70.0 68.9 71.1     
  0.012–0.023 89 70.8 69.6 71.9     
  0.024–0.048 92 71.4 70.2 72.6     
  0.049–0.491 92 71.3 70.1 72.4     
       0.43 0.10 0.76 0.010
  Log-transformed CRP      0.42 0.06 0.79 0.021
  1. aAdjusted by age, BMI, smoking (never, former, current), exercise (none/week, 1–2 times/week, ≥3 times/week), and drinking (non-drinker, sometimes, < 150 g/week, ≥150 g/week). Estimates were calculated with average values of continuous variables
  2. bAdjusted by the factors in adjusted model 1 with folate intake
  3. cAverage relative methylation difference per 1-category increase (included as a continuous variable)