BMC Cancer

Table 1 Assessment of the association between serum CRP concentration and global methylation level with and without adjustment for life-style factors using the general linear model

From: Correlation between global methylation level of peripheral blood leukocytes and serum C reactive protein level modified by MTHFR polymorphism: a cross-sectional study

				95% confidence interval			95% confidence interval
Variable	CRP (mg/dL)	N	Estimated mean methylation (%)	Lower	Upper	β^c	Lower	Upper	P value for trend
Crude model	0.002–0.011	101	69.7	69.0	70.3
	0.012–0.023	89	70.2	69.5	70.9
	0.024–0.048	93	70.7	70.0	71.3
	0.049–0.491	93	70.4	69.8	71.1
						0.28	−0.02	0.58	0.071
	Log-transformed CRP					0.25	−0.07	0.56	0.123
Adjusted model 1^a	0.002–0.011	100	70.1	69.0	71.2
	0.012–0.023	89	70.7	69.6	71.9
	0.024–0.048	92	71.4	70.3	72.6
	0.049–0.491	92	71.3	70.1	72.5
						0.43	0.10	0.76	0.011
	Log-transformed CRP					0.42	0.07	0.78	0.019
Adjusted model 2^b	0.002–0.011	100	70.0	68.9	71.1
	0.012–0.023	89	70.8	69.6	71.9
	0.024–0.048	92	71.4	70.2	72.6
	0.049–0.491	92	71.3	70.1	72.4
						0.43	0.10	0.76	0.010
	Log-transformed CRP					0.42	0.06	0.79	0.021

^aAdjusted by age, BMI, smoking (never, former, current), exercise (none/week, 1–2 times/week, ≥3 times/week), and drinking (non-drinker, sometimes, < 150 g/week, ≥150 g/week). Estimates were calculated with average values of continuous variables
^bAdjusted by the factors in adjusted model 1 with folate intake
^cAverage relative methylation difference per 1-category increase (included as a continuous variable)

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