Table 3 Association of different variables with BRCA1/2 mutation status, N=95a
From: Germline BRCA1/BRCA2 mutations among high risk breast cancer patients in Jordan
Variable | Level | Total | BRCA1/2 mutation status | P-value | |
|---|---|---|---|---|---|
Positive (deleterious and suspected deleterious) | Others (No variant, FP, VUS) | ||||
Age N = 95 | age < =40 | 50 | 13(26.0%) | 37(74.0%) | NS |
age > 40 | 45 | 9(20.0%) | 36 (80.0%) | ||
Triple negative N = 95 | No | 79 | 13 (16.5%) | 66 (83.5%) | 0.001 |
Yes | 16 | 9 (56.3%) | 7 (43.8%) | ||
Triple negative (age < =50 (N = 75)) | No | 60 | 12 (20.0%) | 48 (80.0%) | |
Yes | 15 | 8 (53.3%) | 7 (46.7%) | 0.009 | |
Triple negative (age < =40 (N = 50)) | No | 38 | 7 (18.4%) | 31 (81.6%) | |
Yes | 12 | 6 (50.0%) | 6 (50.0%) | 0.030 | |
Triple negative (family history = Yes (N = 84)) | No | 71 | 13 (18.3%) | 58 (81.7%) | |
Yes | 13 | 9 (69.2%) | 4 (30.8%) | 0.000 | |
Number of relatives with breast and/or ovarian cancer (first and second degree) | Relatives < 2 | 31 | 4 (12.9%) | 27 (87.1%) | NS |
Relatives > = 2 | 64 | 18 (28.1%) | 46 (71.9%) | ||
Family history of breast cancer and/or ovarian cancer (first and second degree) | No | 11 | 11(100%) | 0.063 | |
Yes | 84 | 22 (26.2%) | 62 (73.8%) | ||
Bilateral or second primary breast cancer | no | 80 | 12 (15.0%) | 68 (85.0%) | 0.000 |
yes | 15 | 10 (66.7%) | 5 (33.3%) | ||
Family history of male breast cancer | no | 90 | 20 (22.2%) | 70 (77.8%) | NS |
yes | 5 | 2 (40.0%) | 3 (60.0%) | ||
Family history (age < =40 (N = 50)) | No | 10 | 10(100%) | 0.046 | |
Yes | 40 | 13 (32.5%) | 27 (67.5%) | ||