Skip to main content

Advertisement

Table 3 Association of different variables with BRCA1/2 mutation status, N=95a

From: Germline BRCA1/BRCA2 mutations among high risk breast cancer patients in Jordan

Variable Level Total BRCA1/2 mutation status P-value
Positive (deleterious and suspected deleterious) Others (No variant, FP, VUS)
Age N = 95 age < =40 50 13(26.0%) 37(74.0%) NS
  age > 40 45 9(20.0%) 36 (80.0%)  
Triple negative N = 95 No 79 13 (16.5%) 66 (83.5%) 0.001
Yes 16 9 (56.3%) 7 (43.8%)  
Triple negative (age < =50 (N = 75)) No 60 12 (20.0%) 48 (80.0%)  
Yes 15 8 (53.3%) 7 (46.7%) 0.009
Triple negative (age < =40 (N = 50)) No 38 7 (18.4%) 31 (81.6%)  
Yes 12 6 (50.0%) 6 (50.0%) 0.030
Triple negative (family history = Yes (N = 84)) No 71 13 (18.3%) 58 (81.7%)  
Yes 13 9 (69.2%) 4 (30.8%) 0.000
Number of relatives with breast and/or ovarian cancer (first and second degree) Relatives < 2 31 4 (12.9%) 27 (87.1%) NS
Relatives > = 2 64 18 (28.1%) 46 (71.9%)  
Family history of breast cancer and/or ovarian cancer (first and second degree) No 11   11(100%) 0.063
Yes 84 22 (26.2%) 62 (73.8%)  
Bilateral or second primary breast cancer no 80 12 (15.0%) 68 (85.0%) 0.000
yes 15 10 (66.7%) 5 (33.3%)  
Family history of male breast cancer no 90 20 (22.2%) 70 (77.8%) NS
yes 5 2 (40.0%) 3 (60.0%)  
Family history (age < =40 (N = 50)) No 10   10(100%) 0.046
Yes 40 13 (32.5%) 27 (67.5%)  
  1. FP favor polymorphism, VUS variant of uncertain significance, NS non-significant
  2. aFive patients (patients 061, 063, 020, 070 and 071) were relatives to the index case tested in their families, therefore they were excluded from this analysis, see footnote to Table 2