Table 2 Comparison of background characteristics between the patients with optimal response and suboptimal response
Optimal response | Suboptimal response | |
|---|---|---|
Age, years | ||
Median | 57 | 71 |
Range | 36–67 | 55–83 |
Gender | ||
Male | 1 | 1 |
Female | 2 | 6 |
Primary (colon/rectum) | ||
0 | 2 | |
3 | 5 | |
RAS (wild/mutant) | ||
wild | 2 | 3 |
mutant | 1 | 4 |
Performance status | ||
0 | 0 | 2 |
1 | 3 | 4 |
2 | 0 | 1 |
No. of chemotherapy lines | ||
2 | 0 | 1 |
3 | 0 | 3 |
4 | 2 | 1 |
5 | 1 | 2 |
Cycles of regorafenib | ||
Median | 4 | 1 |
Range | 1–15 | 1–3 |
Reasons for discontinuation | ||
Disease progression | 2 | 3 |
Toxicity | 0 | 4 |
Best response in RECIST | ||
SD | 2 | 2 |
PD | 1 | 5 |
Best change in size | ||
Median | + 16.0% | + 25.5% |
Range | + 1.4% to + 31.5% | −6.2% to + 280.6% |