Table 2 Cox univariate and multivariate regression analyses of prognostic factors and MCM2, MCM6 and MCM7 expression for overall survival in HCC patients
Variables | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
Hazard Ratio (95% CI) | p Value | Hazard Ratio (95% CI) | p Value | |
Age (> 50ys) | 0.89(0.59–1.35) | 0.590 |  |  |
Gender (male) | 1.24 (0.69–2.23) | 0.464 |  |  |
Total tumor size (> 5 cm) | 2.26(1.47–3.49) | < 0.001 | 1.29(0.73–2.27) | 0.390 |
Tumor multiplicity (multiple) | 1.88 (1.14–3.10) | 0.014 | 1.74(0.99–3.08) | 0.056 |
Differentiation (mod./ well vs poor) | 0.60 (0.40–0.89) | 0.012 | 1.01(0.62–1.64) | 0.974 |
TNM stage (I-II vs III-IV) | 0.37 (0.24–0.57) | < 0.001 | 0.51(0.29–0.88) | 0.016 |
Tissue AFP (High) | 1.42(0.96–2.11) | 0.081 |  |  |
Tissue Ki67 (High) | 1.74(1.16–2.59) | 0.007 | 1.20(0.74–1.94) | 0.471 |
MCM2 (High) | 1.59(1.07–2.36) | 0.020 | 1.19(0.74–1.91) | 0.485 |
MCM6 (High) | 1.93(1.29–2.88) | 0.001 | 1.65(1.00–2.72) | 0.048 |
MCM7 (High) | 1.97(1.32–1.95) | 0.001 | 1.50(0.94–2.39) | 0.087 |