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Table 2 Cox univariate and multivariate regression analyses of prognostic factors and MCM2, MCM6 and MCM7 expression for overall survival in HCC patients

From: MCM family in HCC: MCM6 indicates adverse tumor features and poor outcomes and promotes S/G2 cell cycle progression

Variables Univariate Analysis Multivariate Analysis
Hazard Ratio (95% CI) p Value Hazard Ratio (95% CI) p Value
Age (> 50ys) 0.89(0.59–1.35) 0.590   
Gender (male) 1.24 (0.69–2.23) 0.464   
Total tumor size (> 5 cm) 2.26(1.47–3.49) < 0.001 1.29(0.73–2.27) 0.390
Tumor multiplicity (multiple) 1.88 (1.14–3.10) 0.014 1.74(0.99–3.08) 0.056
Differentiation (mod./ well vs poor) 0.60 (0.40–0.89) 0.012 1.01(0.62–1.64) 0.974
TNM stage (I-II vs III-IV) 0.37 (0.24–0.57) < 0.001 0.51(0.29–0.88) 0.016
Tissue AFP (High) 1.42(0.96–2.11) 0.081   
Tissue Ki67 (High) 1.74(1.16–2.59) 0.007 1.20(0.74–1.94) 0.471
MCM2 (High) 1.59(1.07–2.36) 0.020 1.19(0.74–1.91) 0.485
MCM6 (High) 1.93(1.29–2.88) 0.001 1.65(1.00–2.72) 0.048
MCM7 (High) 1.97(1.32–1.95) 0.001 1.50(0.94–2.39) 0.087
  1. Italic values indicate statistical significance