Fig. 4

Kaplan-Meier survival curves with regard to overall survival according to MCM2, MCM6 and MCM7 protein expression in 175 patients with HCC (log-rank test). Specimens were stratified into high or low expression using the median expression level as the cut-off point. Overall survival of patients with high expression of MCM2 (a), MCM6 (b) and MCM7 (c) significantly worse than that with low expression (P = 0.020, 0.001 and 0.001, respectively). d Kaplan-Meier survival curve for specimens stratified into four groups based on the number of three-marker panel (MCM2, MCM6 and MCM7) expressed at a high level (P = 0.001). 0, 1, 2, and 3 indicates the number of MCMs expressed at a high level