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Table 2 Clinical features and follow up data of 41 extra-uterine and extra-ovarian mullerian adenosarcoma according to histological features

From: Primary extra-uterine and extra-ovarian mullerian adenosarcoma: case report and literature review

  Total population Endometriosis P value Overgrowth P value Heterologous sarcomatous differentiation P value
  n = 41 n (%) No n = 16 n (%) Yes n = 25 n (%)   No n = 32 n (%) Yes n = 9 n (%)   No n = 37 n (%) Yes n = 4 n (%)  
Age (mean ± SD), years 44.5 ± 15.0 43.1 ± 15.8 45.5 ± 12.7 0.597 45.4 ± 13.9 41.4 ± 14.6 0.463 46.4 ± 13.0 27.5 ± 11.8 0.009
Size (mean ± SD), mm 12.2 ± 6.9 13.4 ± 8.3 11.0 ± 5.3 0.319 12.5 ± 6.7 11.0 ± 8.1 0.659 11.9 ± 6.8 14.7 ± 8.5 0.517
 Site     0.066    1    1
  Extra-genital 32 (78.0) 15 (93.8) 17 (68.0)   25 (78.1) 7 (77.8)   29 (78.4) 3 (75.0)  
  Vagina 9 (22.0) 1 (6.2) 8 (32.0)   7 (21.9) 2 (22.2)   8 (21.6) 1 (25.0)  
 Endometriosis        1    0.281
  No 16 (39.0) 13(40.6) 3 (33.3)   13 (35.1) 3 (75.0)  
  Yes 25 (61.0) 19 (59.4) 6 (66.7)   24 (64.9) 1 (25.0)  
 Overgrowth     1       1
  No 32 (78.0) 13 (81.3) 19(76.0)    29 (78.4) 3 (75.0)  
  Yes 9 (22.0) 3 (18.7) 6 (24.0)    8 (21.6) 1 (25.0)  
 Treatment     0.557    1    0.101
  Surgery 22 (53.7) 9 (56.3) 13 (52.0)   18 (56.3) 4 (44.4)   19 (51.4) 3 (75.0)  
  Surgery + additional treatments 16 (39.0) 5 (31.2) 11 (44.0)   11 (34.4) 5 (55.6)   16 (43.2) 0 (0.0)  
  No Surgery 3 (7.3) 2 (12.5) 1(4.0)   3 (9.4) 0 (0.0)   2 (5.4) 1 (25.0)  
 Surgical Approach     0.345    1    0.327
  Complete resection 33 (80.5) 11 (68.8) 22 (88.0)   25 (78.1) 8 (88.9)   30 (81.1) 3 (75.0)  
  Partial resection 5 (12.2) 3 (18.7) 2 (8.0)   4 (12.5) 1 (11.1)   5 (13.5) 0 (0.0)  
  No surgery 3 (7.3) 2 (12.5) 1 (4.0)   3 (9.4) 0 (0.0)   2 (5.4) 1 (25.0)  
 Lost in follow up 6 (14.6) 4 2   4 2   6 0  
 Status at last follow up (35 patients)     0.002    0.843    0.278
  FOD 22 (62.9) 3 (25.0) 19 (82.6)   17 (60.7) 5 (71.4)   19 (61.3) 3 (75.0)  
  AWD 4 (11.4) 3 (50.0) 1 (4.3)   4 (14.3) 0 (0.0)   3 (9.7) 1 (25.0)  
  DOD 9 (25.7) 6 (25.0) 3 (13.0)   7 (25.0) 2 (28.6)   9 (29.0) 0 (0.0)  
 Recurrence 18 (51.4) 9 (56.2) 9 (36.0) 0.184 13 (40.6) 5 (55.5) 0.447 15 (45.5) 3 (75.0) 0.340
 More than 1 recurrence 9 (25.7) 4 (28.6) 5 (21.7) 1 5 (17.9) 4 (57.1) 0.294 7 (18.9) 2 (50.0) 1
 Death patients OS (mean ± sd)   7.0 ± 5.7 46.3 ± 63.9 0.151 6.0 ± 4.0 16.7 ± 17.8 0.179 20.1 ± 37.8 *
 Patients with recurrence DFS (mean ± sd)   47.9 ± 63.6 28.0 ± 41.3 0.486 12.2 ± 11.4 11.4 ± 12.6 0.897 11.9 ± 12.1 11.6 ± 10.5 1
  1. AWD alive with disease, DOD died of disease, FOD free of disease
  2. *comparison was not possible, because no patients with heterologous sarcomatous differentiation dead during follow up