Table 2 Classification of endometrial cancer cell lines into four groups
Groups | Cell line | PIK3CA | KRAS | PTEN | PIK3R1 | PIK3R2 | PTEN expression |
|---|---|---|---|---|---|---|---|
Group 1 (PIK3CA-mutated only) | SKUT2 | E545K (hetero) | Wild-type | Wild-type | Wild-type | Wild-type | High |
MFE280 | H1047Y (hetero) | Wild-type | Wild-type | Wild-type | Wild-type | High | |
Group 2a (PTEN-mutated, PTEN-retained) | EN1078D | Wild-type | Wild-type | Y88C | G376R (hetero) | Wild-type | High |
MFE296 | P539R (hetero); I20M (hetero) | Wild-type | R130Q (homo); N322Â fs (hetero) | Wild-type | Wild-type | High | |
ETN1 | Wild-type | Wild-type | I122V (hetero), R130L (hetero); N328Â fs (hetero) | Wild-type | Wild-type | High | |
Group 2b (PTEN-mutated and PTEN-Loss) | AN3CA | Wild-type | Wild-type | R130fs (homo) | REID557del (hetero) | Wild-type | Low |
HEC59 | Wild-type | Wild-type | Y46H (hetero); R233 (hetero); P246L (hetero) | T473S (hetero); K567E (hetero); S460Â fs (hetero) | Wild-type | Low | |
EN | T1025A (hetero) | Wild-type | K266Â fs (hetero) | N260S (hetero) | Wild-type | Low | |
Group 3 (KRAS-mutated) | HEC1A | G1049R (hetero) | G12D (homo) | Wild-type | Wild-type | Wild-type | High |
HEC1B | G1049R (hetero) | G12D (homo) | Wild-type | Wild-type | Wild-type | High | |
HEC50 | Wild-type | G12D (hetero) | Wild-type | E468InsGEYDRLYE (homo) | Wild-type | High | |
Group 4 (Wild-type) | EFE184 | Wild-type | Wild-type | Wild-type | Wild-type | Wild-type | High |
KLE | Wild-type | Wild-type | Wild-type | Wild-type | Wild-type | High |