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Table 2 Classification of endometrial cancer cell lines into four groups

From: Preclinical evaluation and reverse phase protein Array-based profiling of PI3K and MEK inhibitors in endometrial carcinoma in vitro

Groups Cell line PIK3CA KRAS PTEN PIK3R1 PIK3R2 PTEN expression
Group 1 (PIK3CA-mutated only) SKUT2 E545K (hetero) Wild-type Wild-type Wild-type Wild-type High
MFE280 H1047Y (hetero) Wild-type Wild-type Wild-type Wild-type High
Group 2a (PTEN-mutated, PTEN-retained) EN1078D Wild-type Wild-type Y88C G376R (hetero) Wild-type High
MFE296 P539R (hetero); I20M (hetero) Wild-type R130Q (homo); N322 fs (hetero) Wild-type Wild-type High
ETN1 Wild-type Wild-type I122V (hetero), R130L (hetero); N328 fs (hetero) Wild-type Wild-type High
Group 2b (PTEN-mutated and PTEN-Loss) AN3CA Wild-type Wild-type R130fs (homo) REID557del (hetero) Wild-type Low
HEC59 Wild-type Wild-type Y46H (hetero); R233 (hetero); P246L (hetero) T473S (hetero); K567E (hetero); S460 fs (hetero) Wild-type Low
EN T1025A (hetero) Wild-type K266 fs (hetero) N260S (hetero) Wild-type Low
Group 3 (KRAS-mutated) HEC1A G1049R (hetero) G12D (homo) Wild-type Wild-type Wild-type High
HEC1B G1049R (hetero) G12D (homo) Wild-type Wild-type Wild-type High
HEC50 Wild-type G12D (hetero) Wild-type E468InsGEYDRLYE (homo) Wild-type High
Group 4 (Wild-type) EFE184 Wild-type Wild-type Wild-type Wild-type Wild-type High
KLE Wild-type Wild-type Wild-type Wild-type Wild-type High
  1. The 6 cell lines highlighted in bold were selected for further RPPA analyses
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