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Table 2 The association between ESR1 (ERα) and ESR2 (ERβ) mRNA expression and clinico-pathological characteristics

From: Selective oestrogen receptor antagonists inhibit oesophageal cancer cell proliferation in vitro

Variable No. ESR1 (ERα) mRNA expression ESR2 (ERβ) mRNA expression
Normal mucosa Tumour Normal mucosa Tumour
Median (IQR) P b Median (IQR)   Median (IQR) P b Median (IQR) P b
Gender Female 6 11.8 (5.7, 24.5) 0.2 14.6 (6.9, 58.1) 0.37 1.7 (1.1, 2.3) 0.31 4.1 (1.3, 5.9) 0.37
Male 28 6.9 (7.2, 17.8) 15.4 (5.6, 23.2) 1.8 (1.3, 3.0) 2.1 (1.8, 5.0)
Histology AC 28 9.5 (6.5, 18.5) 0.4 14.3 (5.5, 23.6) 0.055 1.8 (1.3, 2.5) 0.39 2.1 (1.5, 5.9) 0.16
SCC 6 11.2 (6.9, 15.3) 22.6 (18.4, 25.2) 1.7 (1.1, 2.5) 3.1 (2.1, 6.0)
T-stagea pT1 8 8.4 (7.6,14.2) 0.24 9.5 (3.3, 15.8) 0.02 1.7 (1.2, 3.6) 0.53 2.0 (0.9, 5.4) 0.085
pT2 3 5.7 (2.5, 13.8) 5.7 (5.3, 8.9) 0.8 (0.7, 3.5) 1.7 (0.5, 1.8)
pT3 23 14.7 (6.3, 18.7) 20 (13, 31) 1.9 (1.35, 27) 3.1 (1.8, 5.6)
LN statusa N0 15 7.8 (6.1, 13.4) 0.01 9.7 (5.4, 19.7) 0.02 1.4 (1.3, 2.7) 0.15 2.0 (1.0, 5.3) 0.11
N1 19 15.9 (7.8, 21.3) 18.2 (7.3, 40.5) 1.9 (1.4, 2.4) 3.1 (1.8, 7
Gradea Moderate 25 10.2 (6.7, 18.4)   15.3 (6.0, 22.5)   1.8 (1.2, 2.7)   2.8 (1.8, 6.1)  
Poor 9 7.8 (5.4, 16.3) 19.7 (6.0, 36.6) 1.9 (1.3, 2.6) 1.8 (1.0, 5.1)
VIa No 21 8.8 (6.2, 22.3) 0.42 14.8 (5.1, 21.4) 0.07 1.9 (1.3, 2.9) 0.41 2.0 (0.9, 4.4) 0.01
Yes 13 10.2 (7.8, 16.9) 17.0 (10.7, 28.1) 1.8 (1.3, 2.3) 3.3 (2.9, 7.1)
BM Yes 13 13.4 (6.4, 21.3 0.26 14.6 (6.1, 18.7) 0.31 2.1 (1.3, 5.9) 0.12 1.7 (1.2, 2.9) 0.054
No 15 6.3 (2.5, 16.6) 14.8 (5.1, 44.4) 1.9 (1.3, 2.3) 2.8 (1.7, 5.5)
CRM No 23 13.4 (6.7, 21.3) 0.21 14.8 (5.7, 20.3) 0.12 1.9 (1.2, 2.7) 0.44 2.0 (1.0, 7.2) 0.09
Yes 11 8.6 (6.0, 16.6) 22.5 (7.3, 25.7) 1.8 (1.3, 2.4 2.1 (1.5, 3.1)
  1. AC oesophageal adenocarcinoma, SCC squamous cell carcinoma, pT stage is tumour’s depth, LN status is lymph node involvement, BM, Barrett’s metaplasia, CRM, circumferential resection margin, IQR interquartile range
  2. aThe 7th TNM Classification of Malignant Tumours proposed by the AJCC/UICC (Sobin LH, 2010)
  3. b Analysis performed Mann Whitney U test and Kruskal-Wallis test as appropriate