From: Selective oestrogen receptor antagonists inhibit oesophageal cancer cell proliferation in vitro
Variable | No. | ESR1 (ERα) mRNA expression | ESR2 (ERβ) mRNA expression | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Normal mucosa | Tumour | Normal mucosa | Tumour | |||||||
Median (IQR) | P b | Median (IQR) | Â | Median (IQR) | P b | Median (IQR) | P b | |||
Gender | Female | 6 | 11.8 (5.7, 24.5) | 0.2 | 14.6 (6.9, 58.1) | 0.37 | 1.7 (1.1, 2.3) | 0.31 | 4.1 (1.3, 5.9) | 0.37 |
Male | 28 | 6.9 (7.2, 17.8) | 15.4 (5.6, 23.2) | 1.8 (1.3, 3.0) | 2.1 (1.8, 5.0) | |||||
Histology | AC | 28 | 9.5 (6.5, 18.5) | 0.4 | 14.3 (5.5, 23.6) | 0.055 | 1.8 (1.3, 2.5) | 0.39 | 2.1 (1.5, 5.9) | 0.16 |
SCC | 6 | 11.2 (6.9, 15.3) | 22.6 (18.4, 25.2) | 1.7 (1.1, 2.5) | 3.1 (2.1, 6.0) | |||||
T-stagea | pT1 | 8 | 8.4 (7.6,14.2) | 0.24 | 9.5 (3.3, 15.8) | 0.02 | 1.7 (1.2, 3.6) | 0.53 | 2.0 (0.9, 5.4) | 0.085 |
pT2 | 3 | 5.7 (2.5, 13.8) | 5.7 (5.3, 8.9) | 0.8 (0.7, 3.5) | 1.7 (0.5, 1.8) | |||||
pT3 | 23 | 14.7 (6.3, 18.7) | 20 (13, 31) | 1.9 (1.35, 27) | 3.1 (1.8, 5.6) | |||||
LN statusa | N0 | 15 | 7.8 (6.1, 13.4) | 0.01 | 9.7 (5.4, 19.7) | 0.02 | 1.4 (1.3, 2.7) | 0.15 | 2.0 (1.0, 5.3) | 0.11 |
N1 | 19 | 15.9 (7.8, 21.3) | 18.2 (7.3, 40.5) | 1.9 (1.4, 2.4) | 3.1 (1.8, 7 | |||||
Gradea | Moderate | 25 | 10.2 (6.7, 18.4) | Â | 15.3 (6.0, 22.5) | Â | 1.8 (1.2, 2.7) | Â | 2.8 (1.8, 6.1) | Â |
Poor | 9 | 7.8 (5.4, 16.3) | 19.7 (6.0, 36.6) | 1.9 (1.3, 2.6) | 1.8 (1.0, 5.1) | |||||
VIa | No | 21 | 8.8 (6.2, 22.3) | 0.42 | 14.8 (5.1, 21.4) | 0.07 | 1.9 (1.3, 2.9) | 0.41 | 2.0 (0.9, 4.4) | 0.01 |
Yes | 13 | 10.2 (7.8, 16.9) | 17.0 (10.7, 28.1) | 1.8 (1.3, 2.3) | 3.3 (2.9, 7.1) | |||||
BM | Yes | 13 | 13.4 (6.4, 21.3 | 0.26 | 14.6 (6.1, 18.7) | 0.31 | 2.1 (1.3, 5.9) | 0.12 | 1.7 (1.2, 2.9) | 0.054 |
No | 15 | 6.3 (2.5, 16.6) | 14.8 (5.1, 44.4) | 1.9 (1.3, 2.3) | 2.8 (1.7, 5.5) | |||||
CRM | No | 23 | 13.4 (6.7, 21.3) | 0.21 | 14.8 (5.7, 20.3) | 0.12 | 1.9 (1.2, 2.7) | 0.44 | 2.0 (1.0, 7.2) | 0.09 |
Yes | 11 | 8.6 (6.0, 16.6) | 22.5 (7.3, 25.7) | 1.8 (1.3, 2.4 | 2.1 (1.5, 3.1) |