Prevalence of pathogenic BRCA1/2 germline mutations among 802 women with unilateral triple-negative breast cancer without family cancer history

Table 3 Expected annual number of women with TNBC and gBRCA mutation in Germany

Age group	Number of newly diagnosed BC cases in 2012 ^a	% TNBC among all BC cases ^b	% of TNBC w/o FH ^c	Number of TNBC cases w/o FH	% BRCA1/2 mutation carriers among TNBC cases w/o FH ^d	Number of BRCA1/2 mutation carriers among TNBC cases without FH
< 40	2462	19.8	62.2	302	26.3	79
40–49	9757	10.5	56.8	580	12.1	70
50–59	15,059	9.0	65.8	891	6.9	61
60–69	16,497	7.0	71.9	835	3.8	32
70–79	15,420	6.9	71.9	768	2.1	16

FH family history, BC breast cancer, TNBC triple-negative breast cancer
^aGerman Centre for Cancer Registry Data at the Robert Koch-Institute, Berlin, Germany
^bMunich Cancer Registry, MCR, Munich, Germany
^cCouch et al. [13]
^dpresent study

ISSN: 1471-2407