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Table 2 Frequency distribution and associations of GC SNP rs2282679 with CRC risk (overall and by molecularly defined subtypes)

From: Association of rs2282679 A>C polymorphism in vitamin D binding protein gene with colorectal cancer risk and survival: effect modification by dietary vitamin D intake

rs2282679 Genotype/Allele Cases
N(%)
Controls
N(%)
OR (95% CI)a OR (95% CI)b
All cases vs. controls     
 AA 309 (48.5) 245 (50.1) 1.00 1.00
 AC 282 (44.3) 208 (42.5) 1.08 (0.82–1.41) 1.10 (0.83–1.47)
 CC 46 (7.2) 36 (7.4) 1.06 (0.63–1.77) 1.21 (0.70–2.09)
P trendc    0.647 0.403
 CC + AC (vs. AA) 328 (51.5) 244 (49.9) 1.07 (0.83–1.39) 1.12 (0.85–1.47)
 CC (vs. AC + AA) 46 (7.2) 36 (7.4) 1.02 (0.62–1.68) 1.15 (0.68–1.97)
 Per C allele    1.05 (0.85–1.29) 1.10 (0.88–1.37)
BRAF V600E mutant cases vs. controls    
 AA 25 (46.3) 245 (50.1) 1.00 1.00
 CC + ACd 29 (53.7) 244 (49.9) 1.03 (0.54–1.96) 1.10 (0.56–2.16)
BRAF wild-type cases vs. controls    
 AA 223 (50.1) 245 (50.1) 1.00 1.00
 CC + ACd 222 (49.9) 244 (49.9) 1.08 (0.82–1.42) 1.10 (0.82–1.47)
MSI-H cases vs. controls     
 AA 31 (50.8) 245 (50.1) 1.00 1.00
 CC + ACd 30 (49.2) 244 (49.9) 0.99 (0.56–1.80) 1.03 (0.56–1.90)
MSS/MSI-Low cases vs. controls    
 AA 223 (50.0) 245 (50.1) 1.00 1.00
 CC + ACd 223 (50.0) 244 (49.9) 1.09 (0.83–1.44) 1.15 (0.86–1.53)
  1. Abbreviations: CRC colorectal cancer, OR odds ratio, MSI-H microsatellite instability-high, MSS/MSI-L microsatellite stable/microsatellite instability-low
  2. aCrude model adjusted for age and sex
  3. bMultivariable model additionally adjusted for family history of CRC, screening procedure, multivitamin use, folic acid intake, smoking history, and education attainment where applicable
  4. cLinear trend tested by modeling the ordinal variables of genotype dose as a continuous variable
  5. dCC and AC genotypes were analyzed jointly because of limited sample size in some subgroups