Association of rs2282679 A>C polymorphism in vitamin D binding protein gene with colorectal cancer risk and survival: effect modification by dietary vitamin D intake

Table 2 Frequency distribution and associations of GC SNP rs2282679 with CRC risk (overall and by molecularly defined subtypes)

rs2282679 Genotype/Allele	Cases N(%)	Controls N(%)	OR (95% CI)^a	OR (95% CI)^b
All cases vs. controls
AA	309 (48.5)	245 (50.1)	1.00	1.00
AC	282 (44.3)	208 (42.5)	1.08 (0.82–1.41)	1.10 (0.83–1.47)
CC	46 (7.2)	36 (7.4)	1.06 (0.63–1.77)	1.21 (0.70–2.09)
P _trend^c			0.647	0.403
CC + AC (vs. AA)	328 (51.5)	244 (49.9)	1.07 (0.83–1.39)	1.12 (0.85–1.47)
CC (vs. AC + AA)	46 (7.2)	36 (7.4)	1.02 (0.62–1.68)	1.15 (0.68–1.97)
Per C allele			1.05 (0.85–1.29)	1.10 (0.88–1.37)
BRAF V600E mutant cases vs. controls
AA	25 (46.3)	245 (50.1)	1.00	1.00
CC + AC^d	29 (53.7)	244 (49.9)	1.03 (0.54–1.96)	1.10 (0.56–2.16)
BRAF wild-type cases vs. controls
AA	223 (50.1)	245 (50.1)	1.00	1.00
CC + AC^d	222 (49.9)	244 (49.9)	1.08 (0.82–1.42)	1.10 (0.82–1.47)
MSI-H cases vs. controls
AA	31 (50.8)	245 (50.1)	1.00	1.00
CC + AC^d	30 (49.2)	244 (49.9)	0.99 (0.56–1.80)	1.03 (0.56–1.90)
MSS/MSI-Low cases vs. controls
AA	223 (50.0)	245 (50.1)	1.00	1.00
CC + AC^d	223 (50.0)	244 (49.9)	1.09 (0.83–1.44)	1.15 (0.86–1.53)

Abbreviations: CRC colorectal cancer, OR odds ratio, MSI-H microsatellite instability-high, MSS/MSI-L microsatellite stable/microsatellite instability-low
^aCrude model adjusted for age and sex
^bMultivariable model additionally adjusted for family history of CRC, screening procedure, multivitamin use, folic acid intake, smoking history, and education attainment where applicable
^cLinear trend tested by modeling the ordinal variables of genotype dose as a continuous variable
^dCC and AC genotypes were analyzed jointly because of limited sample size in some subgroups

ISSN: 1471-2407