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Table 2 Most frequently mutated genes in cohort1 sorted by occurrence in metastases

From: Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs)

  Metastasis n = 10 (%) Primary tumors n = 10 (%) Primary tumors TCGA (%)
KMT2C 6 (60) 1 (10) 8
AFF2 3 (30) 3 (30) 2
KMT2A 3 (30) 1 (10) 2
MED12 3 (30) 1 (10) 2
ASXL1 3 (30) 1 (10) 1
FBXO11 3 (30) 0 1
TP53 2 (20) 1 (10) 35
ARID1A 2 (20) 1 (10) 4
NF1 2 (20) 1 (10) 3
AKAP13 2 (20) 0 2
APC 2 (20) 1 (10) 2
ARID1B 2 (20) 1 (10) 2
ATRX 2 (20) 1 (10) 2
CDK12 2 (20) 0 2
KDM6A 2 (20) 0 2
CDH1 1 (10) 0 7
PIK3CA 0 1 (10) 36
AKAP12 2 (20) 0 1
ALK 2 (20) 1 (10) 1
ARID2 2 (20) 1 (10) 1
BAP1 2 (20) 0 1
CAMTA1 2 (20) 1 (10) 1
CLTC 2 (20) 0 1
DICER1 2 (20) 0 1
EML4 2 (20) 0 1
EPS15 2 (20) 0 1
GNAS 2 (20) 0 1
KDM5A 2 (20) 1 (10) 1
KDR 2 (20) 0 1
MET 2 (20) 0 1
MYH11 2 (20) 0 1
NIN 2 (20) 0 1
NUMA1 2 (20) 0 1
NUP98 2 (20) 0 1
PCSK7 2 (20) 3 (30) 1
PDGFRB 2 (20) 1 (10) 1
  1. Number of mutated samples n = 10, (%). The third column lists the reported mutation frequencies in TCGA breast cancer [1]
  2. MET metastasis, PT primary tumor, TCGA the cancer genome atlas