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Table 2 Most frequently mutated genes in cohort1 sorted by occurrence in metastases

From: Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs)

 

Metastasis n = 10 (%)

Primary tumors n = 10 (%)

Primary tumors TCGA (%)

KMT2C

6 (60)

1 (10)

8

AFF2

3 (30)

3 (30)

2

KMT2A

3 (30)

1 (10)

2

MED12

3 (30)

1 (10)

2

ASXL1

3 (30)

1 (10)

1

FBXO11

3 (30)

0

1

TP53

2 (20)

1 (10)

35

ARID1A

2 (20)

1 (10)

4

NF1

2 (20)

1 (10)

3

AKAP13

2 (20)

0

2

APC

2 (20)

1 (10)

2

ARID1B

2 (20)

1 (10)

2

ATRX

2 (20)

1 (10)

2

CDK12

2 (20)

0

2

KDM6A

2 (20)

0

2

CDH1

1 (10)

0

7

PIK3CA

0

1 (10)

36

AKAP12

2 (20)

0

1

ALK

2 (20)

1 (10)

1

ARID2

2 (20)

1 (10)

1

BAP1

2 (20)

0

1

CAMTA1

2 (20)

1 (10)

1

CLTC

2 (20)

0

1

DICER1

2 (20)

0

1

EML4

2 (20)

0

1

EPS15

2 (20)

0

1

GNAS

2 (20)

0

1

KDM5A

2 (20)

1 (10)

1

KDR

2 (20)

0

1

MET

2 (20)

0

1

MYH11

2 (20)

0

1

NIN

2 (20)

0

1

NUMA1

2 (20)

0

1

NUP98

2 (20)

0

1

PCSK7

2 (20)

3 (30)

1

PDGFRB

2 (20)

1 (10)

1

  1. Number of mutated samples n = 10, (%). The third column lists the reported mutation frequencies in TCGA breast cancer [1]
  2. MET metastasis, PT primary tumor, TCGA the cancer genome atlas
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BMC Cancer

ISSN: 1471-2407

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