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Fig. 2 | BMC Cancer

Fig. 2

From: Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs)

Fig. 2

Gene view of AKAP mutations and AKAP protein regions and domains. Drop symbols indicating location of amino acid exchange light green: mutation present only in metastasis; dark green: mutation present in both primary tumor and corresponding metastasis; blue: SNP reported association with familiar breast cancer [46, 48, 66]. PKA-RI/II: protein kinase A regulatory subunit I/II; WSK: short conserved WXSXK motif in protein kinase A binding proteins (AKAPs); ZF: Zinc finger repeats; MCM2: minichromosome maintenance complex 2 [33]; DH: Dbl homology domain (RhoGEF); PH: Pleckstrin homology domain; Protein kinase interacting domains are provided from uniprotKB with additional domains from [32]**. EGFR interacting domain from [63]

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