Table 2 Oncogenic or tumor suppressor miRNAs analysed in the study: effect, targets and associated events

miR-10b

Oncogenic

HOXD10

Metastasis induction

[58]

miR-19a

Oncogenic

PTEN

Cell proliferation, Th1 immune response (innate immunity)

[20, 22, 59,60,61]

miR-20a

Tumor suppressor

E2F

Proliferation repression

[33]

miR-21

Oncogenic

TPM1, PDCD4, TIMP3, PTEN

Cell proliferation, migration, EMT, apoptosis inhibition, Treg cell activation

[20, 62,63,64]

miR-22

Oncogenic

miR-200, ERa, TET

Cell proliferation, EMT

[30, 65]

miR-127

Tumor suppressor

BCL-6

Proliferation, senescence, chemo- and radio-resistance, B cell activation

[31, 32]

miR-155

Oncogenic

STAT-3

Inflammation, B cell activation (innate/adaptive immunity)

[24, 36]

miR-200b

Tumor suppressor

E-cadherin, ZEB1, ZEB2

EMT, tumor growth, metastasis

[66, 67]