Nine primary malignant neoplasms-involving the esophagus, stomach, colon, rectum, prostate, and external ear canal-without microsatellite instability: a case report

Table 2 Histologic types and genetic characteristics of the cancers

Organ	Histology	Immunohistochemistry		Mutation		MSI
Organ	Histology	p53	Nuclear β-catenin	KRAS	BRAF	MSI
Esophagus 1	SCC	+	–	Wt	Wt	MSS
Esophagus 2	SCC	–	–	Wt	Wt	MSS
Stomach 1	AC	+	–	Wt	Wt	MSS
Ear canal	SCC	–	–	Wt	Wt	MSS
Esophagus 3	SCC	–	–	Wt	Wt	MSS
Rectum	AC	+	+	G12C	Wt	MSS
Stomach 2	AC	–	–	G12C	Wt	MSS
Prostate	AC	–	–	Wt	Wt	MSS
Colon	AC	–	+	G13 V	Wt	MSS

The histologic, immunohistochemical (p53, β-catenin), and mutational analysis (KRAS, BRAF, and microsatellite status) characteristics of surgically and endoscopically removed tumor tissues from a man diagnosed with nine metachronous primary malignant lesions
SCC, squamous cell carcinoma; AC, adenocarcinoma; Wt, wild type; MSI, microsatellite instability; MSS, microsatellite stable

ISSN: 1471-2407