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Table 4 Prediction of all-cause mortality after adding continuous or dichotomous E-cadherin measurements to standard diagnostic tests of cancer cell detachment from colorectal primary tumors (n = 188)

From: Diagnostic accuracy and prediction increment of markers of epithelial-mesenchymal transition to assess cancer cell detachment from primary tumors

  E-cadherin Variable Added to Standard Tests
   Dichotomous E-cadherin Cut Point
Continuous 0.52 0.60 0.85
C-Index, % (95% CI)a 66 (58, 72) 51 (41, 59) 54 (45, 62) 56 (48, 63)
Reclassification Metricb
 Number (%) moved to higher risk category 47 (25) 11 (6) 27 (14) 41 (22)
 Number (%) moved to lower risk category 55 (29) 93 (49) 83 (44) 70 (37)
 Total number (%) reclassified 102 (54) 104 (55) 110 (59) 111 (59)
 Reclassification Calibration Statistic P-value 0.1 0.1 0.1 0.2
 Event Net Reclassification Index, % (95% CI) 14 (−11, 30) −22 (−38, −7) −7 (−23, 10) 3 (−15, 21)
 Non-Event Net Reclassification Index, % (95% CI) 13 (3, 35) 54 (44, 63) 41 (29, 52) 24 (12, 37)
 Integrated Discrimination Improvement, % (95% CI) 3.4 (1.9, 5.6) 4.3 (2.2, 6.8) 3.4 (1.8, 5.3) 3.7 (1.7, 5.9)
  1. E-cadherin measured on a continuous average intensity scale of 0–3, then modeled as either continuous or dichotomized (EMT positive versus EMT negative) at a given cut point. For dichotomous E-cadherin, EMT positive status was expression below the cut point while EMT negative status was expression at or above the cut point. 62 subjects died within 5 years of diagnosis
  2. aEach c-index value in the table is for a Cox model estimating 5-year risk of all-cause mortality based on standard diagnostic tests of cancer cell detachment (lymph node evaluation and radiologic imaging) plus the respective continuous or dichotomous E-cadherin variable. C-index for a model of standard diagnostic tests only was 45% (95% CI 36%, 53%)
  3. bReclassification metrics compare a Cox model estimating 5-year risk of all-cause mortality based on standard diagnostic tests of cancer cell detachment (lymph node evaluation and radiologic imaging) to a Cox model based on standard diagnostic tests plus continuous or dichotomous E-cadherin status defined by a given cut point. Mortality risk categories were 0 – 20%, 20 – 30%, 30 – 40%, and > 40%