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Table 2 Distribution of molecular alterations between right-sided and left-sided metastatic colorectal cancer

From: Sidedness and TP53 mutations impact OS in anti-EGFR but not anti-VEGF treated mCRC - an analysis of the KRAS registry of the AGMT (Arbeitsgemeinschaft Medikamentöse Tumortherapie)

   All (n = 161) Right-sided mCRC (n = 38) Left-sided mCRC (n = 123) p-value
Extended RAS status Wild-typea 89 (58) 19 (50) 70 (60) 0.352b
Mutanta 65 (42) 19 (50) 46 (40)
Not available 7 0 7
KRAS Exon 2 Wild-typea 97 (62) 20 (53) 77 (65) 0.229b
Mutanta 59 (38) 18 (47) 41 (35)
Not available 5 0 5
KRAS Exon 3 Wild-typea 145 (99) 38 (100) 107 (99) 1.000b
Mutanta 1 (1) 0 (0) 1 (1)
Not available 15 0 15
KRAS Exon 4 Wild-typea 144 (98) 37 (97) 107 (98) 1.000b
Mutanta 3 (2) 1 (3) 2 (2)
Not available 14 0 14
NRAS Exon 2 Wild-typea 144 (99) 38 (100) 106 (98) 1.000b
Mutanta 2 (1) 0 (0) 2 (2)
Not available 15 0 15
NRAS Exon 3 Wild-typea 145 (99) 38 (100) 107 (99) 1.000b
Mutanta 1 (1) 0 (0) 1 (1)
Not available 15 0 15
NRAS Exon 4 Wild-typea 146 (100) 38 (100) 108 (100) 1.000b
Mutanta 0 (0) 0 (0) 0 (0)
Not available 15 0 15
TP53 mutation Wild-typea 84 (60) 29 (78) 55 (53) 0.012b
Mutanta 57 (40) 8 (22) 49 (47)
Not available 20 1 19
TP53 Exon 5 Wild-typea 113 (80) 32 (86) 81 (78) 0.375b
Mutanta 28 (20) 5 (14) 23 (22)
Not available 20 1 19
TP53 Exon 6 Wild-typea 135 (96) 36 (97) 99 (95) 1.000b
Mutanta 6 (4) 1 (3) 5 (5)
Not available 20 1 19
TP53 Exon 7 Wild-typea 131 (93) 35 (95) 96 (92) 0.728b
Mutanta 10 (7) 2 (5) 8 (8)  
Not available 20 1 19  
TP53 Exon 8 Wild-typea 126 (89) 37 (100) 89 (86) 0.012b
Mutanta 15 (11) 0 (0) 15 (14)
Not available 20 1 19  
TP53 Exon 9 Wild-typea 86 (100) 25 (100) 61 (100) NA
Mutanta 0 (0) 0 (0) 0 (0)
Not available 75 13 62
BRAF Exon 15 Wild-typea 136 (99) 34 (100) 102 (99) 1.000b
Mutanta 1 (1) 0 (0) 1 (1)
Not available 24 4 20
PI3K Wild-typea 129 (96) 34 (97) 95 (95) 0.677b
Mutanta 6 (4) 1 (3) 5 (5)
Not available 26 3 23
PI3K Exon 9 Wild-typea 132 (99) 34 (100) 98 (98) 1.000b
Mutanta 2 (1) 0 (0) 2 (2)
Not available 27 4 23
PI3K Exon 20 Wild-typea 137 (97) 36 (97) 101 (97) 1.000b
Mutanta 4 (3) 1 (3) 3 (3)
Not available 20 1 19
  1. Percentage in brackets, aincluded categories, btwo-sided Fisher’s exact test, Χ2-test with Yates’ correction in all other cases