Table 2 Distribution of molecular alterations between right-sided and left-sided metastatic colorectal cancer

Extended RAS status

Wild-type^a

89 (58)

19 (50)

70 (60)

Mutant^a

65 (42)

19 (50)

46 (40)

Not available

7

0

7

KRAS Exon 2

Wild-type^a

97 (62)

20 (53)

77 (65)

Mutant^a

59 (38)

18 (47)

41 (35)

Not available

5

0

5

KRAS Exon 3

Wild-type^a

145 (99)

38 (100)

107 (99)

Mutant^a

1 (1)

0 (0)

1 (1)

Not available

15

0

15

KRAS Exon 4

Wild-type^a

144 (98)

37 (97)

107 (98)

Mutant^a

3 (2)

1 (3)

2 (2)

Not available

14

0

14

NRAS Exon 2

Wild-type^a

144 (99)

38 (100)

106 (98)

Mutant^a

2 (1)

0 (0)

2 (2)

Not available

15

0

15

NRAS Exon 3

Wild-type^a

145 (99)

38 (100)

107 (99)

Mutant^a

1 (1)

0 (0)

1 (1)

Not available

15

0

15

NRAS Exon 4

Wild-type^a

146 (100)

38 (100)

108 (100)

Mutant^a

0 (0)

0 (0)

0 (0)

Not available

15

0

15

TP53 mutation

Wild-type^a

84 (60)

29 (78)

55 (53)

Mutant^a

57 (40)

8 (22)

49 (47)

Not available

20

1

19

TP53 Exon 5

Wild-type^a

113 (80)

32 (86)

81 (78)

Mutant^a

28 (20)

5 (14)

23 (22)

Not available

20

1

19

TP53 Exon 6

Wild-type^a

135 (96)

36 (97)

99 (95)

Mutant^a

6 (4)

1 (3)

5 (5)

Not available

20

1

19

TP53 Exon 7

Wild-type^a

131 (93)

35 (95)

96 (92)

Mutant^a

10 (7)

2 (5)

8 (8)

Not available

20

1

19

TP53 Exon 8

Wild-type^a

126 (89)

37 (100)

89 (86)

Mutant^a

15 (11)

0 (0)

15 (14)

Not available

20

1

19

TP53 Exon 9

Wild-type^a

86 (100)

25 (100)

61 (100)

Mutant^a

0 (0)

0 (0)

0 (0)

Not available

75

13

62

BRAF Exon 15

Wild-type^a

136 (99)

34 (100)

102 (99)

Mutant^a

1 (1)

0 (0)

1 (1)

Not available

24

4

20

PI3K

Wild-type^a

129 (96)

34 (97)

95 (95)

Mutant^a

6 (4)

1 (3)

5 (5)

Not available

26

3

23

PI3K Exon 9

Wild-type^a

132 (99)

34 (100)

98 (98)

Mutant^a

2 (1)

0 (0)

2 (2)

Not available

27

4

23

PI3K Exon 20

Wild-type^a

137 (97)

36 (97)

101 (97)

Mutant^a

4 (3)

1 (3)

3 (3)

Not available

20

1

19