Fig. 4
Overexpression of Survivin causes DNA damage. a Indirect immunofluorescence analysis showing increased numbers of γH2AX foci in SVGp12, HCT116 and HCT116p53−/− cells 72 h after transduction with Survivin. γH2AX foci are marked with arrows. Upper panel: empty vector-transduced controls; lower panel: Survivin-transduced cells. DAPI (DNA, blue), FITC (γH2AX, white foci). b Graph depicting the mean number of foci and SEM per cell in each cell line. **p < 0.01; ***p < 0.001