Fig. 2
From: MicroRNA-200a confers chemoresistance by antagonizing TP53INP1 and YAP1 in human breast cancer
Ectopic expression of miR-200a promoted chemoresistance in breast cancer cell lines to multiple agents. Inhibition ratio of miR-200a and miR-Ctrl transfected MDA-MB-231 (a) and ZR-75-30 (b) after treating with chemo drugs 72 h. The drug concentrations were gemcitabine 5 μM, cis-platin 5 μM, and paclitaxel 60 nM, respectively. And the lysates were collected from MDA-MB-231(c) and ZR-75-30 (d) cells transfected with miR-200a and miR-Ctrl to analyze the activation of Caspases-3 and -7 using the Caspase GLO assay system. Data are mean ± SD of triplicate experiments. *p < 0.05; **p < 0.01