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Table 2 Immunohistochemical distribution of moesin and podoplanin at invasive front tumor of 84 oral squamous cell carcinoma, according to microscopical variables. A.C. Camargo Cancer Hospital, São Paulo, Brazil, 1963 to 2012

From: Moesin expression by tumor cells is an unfavorable prognostic biomarker for oral cancer

Variable Moesin p Podoplanin p
Weak Strong Weak Strong
N % N % N % N %
Vascular Embolization
 Yes 25 64.5 28 63.6 0.914 35 71.4 18 51.4 0.061
 No 15 37.5 16 36.4 14 28.6 17 48.6
Perineural Infiltration
 Yes 28 70 29 65.9 0.688 34 69.4 23 65.7 0.722
 No 12 30 15 43.1 15 30.6 12 34.3
Muscular Infiltration
 Yes 31 77.5 38 86.4 0.289 45 91.8 24 68.6 0.006
 No 9 22.5 6 13.6 4 8.2 11 31.4
Bone Infiltration
 Yes 2 5 3 6.8 0.999 1 2 4 11.4 0.155
 No 38 95 41 93.2 48 98 31 88.6
Lymph node Involvementa
 pN0 21 55.3 22 51.2 0.712 20 41.7 23 69.7 0.013
 pN+ 17 44.7 21 48.8 28 58.3 10 30.3
TOTAL 40 100 44 100   49 100 35 100  
  1. N: Number of tumors; p: value obtained by chi-squares test or Fischer’s exact test. pN0: patients without node metastasis; pN+: patients with node metastasis
  2. aExcluded patients who were not submitted to elective neck dissection
  3. p<0.05 was considered statistically significant
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