Moesin expression by tumor cells is an unfavorable prognostic biomarker for oral cancer

BMC Cancer

Table 2 Immunohistochemical distribution of moesin and podoplanin at invasive front tumor of 84 oral squamous cell carcinoma, according to microscopical variables. A.C. Camargo Cancer Hospital, São Paulo, Brazil, 1963 to 2012

Variable	Moesin				p	Podoplanin				p
	Weak		Strong			Weak		Strong
	N	%	N	%		N	%	N	%
Vascular Embolization
Yes	25	64.5	28	63.6	0.914	35	71.4	18	51.4	0.061
No	15	37.5	16	36.4	0.914	14	28.6	17	48.6	0.061
Perineural Infiltration
Yes	28	70	29	65.9	0.688	34	69.4	23	65.7	0.722
No	12	30	15	43.1	0.688	15	30.6	12	34.3	0.722
Muscular Infiltration
Yes	31	77.5	38	86.4	0.289	45	91.8	24	68.6	*0.006*
No	9	22.5	6	13.6	0.289	4	8.2	11	31.4	*0.006*
Bone Infiltration
Yes	2	5	3	6.8	0.999	1	2	4	11.4	0.155
No	38	95	41	93.2	0.999	48	98	31	88.6	0.155
Lymph node Involvement^a
pN0	21	55.3	22	51.2	0.712	20	41.7	23	69.7	*0.013*
pN+	17	44.7	21	48.8	0.712	28	58.3	10	30.3	*0.013*
TOTAL	40	100	44	100		49	100	35	100

N: Number of tumors; p: value obtained by chi-squares test or Fischer’s exact test. pN0: patients without node metastasis; pN+: patients with node metastasis
^aExcluded patients who were not submitted to elective neck dissection
p<0.05 was considered statistically significant

ISSN: 1471-2407