The prognostic value of TP53 mutations in hypopharyngeal squamous cell carcinoma

BMC Cancer

Table 2 Clinicopathological parameters according to TP53 mutation status

Clinicopathological features		Total (n = 57)	TP53 status		P value
Clinicopathological features		Total (n = 57)	Wild-type (n = 18)	Mutation (n = 39)	P value
Age	Range (median)		47–83 (70)	46–84 (68)	0.45**
Subsites	PS	27	12	15	0.25
	PC	5	0	5
	PW	15	6	9
T	T1–3	40	14	26	0.30*
T	T4	17	4	13	0.30*
N	N0/1	32	13	19	0.15
N	N2/3	25	5	20	0.15
Stage	I/II	5	5	0	0.002*
Stage	III/IV	52	13	39	0.002*
Tumor differentiation	W./M. SCC	52	15	37	0.31*
Tumor differentiation	P. SCC	5	3	2	0.31*
Margin	Negative	46	14	32	0.73
Margin	Positive	11	4	7	0.73
No. of metastatic LNs	≤3	43	14	29	1.00
No. of metastatic LNs	≥4	14	4	10	1.00
ENE	Absent	42	16	26	0.11*
ENE	Present	15	2	13	0.11*
PORT/CRT	Absent	41	14	27	0.25
PORT/CRT	Present	16	4	12	0.25
Anamnestic SCC	Absent	42	17	25	0.02*
Anamnestic SCC	Present	15	1	14	0.02*

PS pyriform sinus, PC postcricoid, PW posterior wall, T tumor classification, N nodal classification, Stage stage classification, W well differentiated, M moderately differentiated, P poorly differentiated, SCC squamous cell carcinoma, No number, LN lymph node, ENE extranodal extension, PORT/CRT postoperative radiotherapy/chemoradiotherapy, Anamnestic SCC anamnestic squamous cell carcinoma arising from esophagus and head and neck region, *: Fisher’s exact tests were used. **: Mann-Whitney’s U test was used

ISSN: 1471-2407