From: The prognostic value of TP53 mutations in hypopharyngeal squamous cell carcinoma
Clinicopathological features | Total (n = 57) | TP53 status | P value | ||
---|---|---|---|---|---|
Wild-type (n = 18) | Mutation (n = 39) | ||||
Age | Range (median) |  | 47–83 (70) | 46–84 (68) | 0.45** |
Subsites | PS | 27 | 12 | 15 | 0.25 |
PC | 5 | 0 | 5 | ||
PW | 15 | 6 | 9 | ||
T | T1–3 | 40 | 14 | 26 | 0.30* |
T4 | 17 | 4 | 13 | ||
N | N0/1 | 32 | 13 | 19 | 0.15 |
N2/3 | 25 | 5 | 20 | ||
Stage | I/II | 5 | 5 | 0 | 0.002* |
III/IV | 52 | 13 | 39 | ||
Tumor differentiation | W./M. SCC | 52 | 15 | 37 | 0.31* |
P. SCC | 5 | 3 | 2 | ||
Margin | Negative | 46 | 14 | 32 | 0.73 |
Positive | 11 | 4 | 7 | ||
No. of metastatic LNs | ≤3 | 43 | 14 | 29 | 1.00 |
≥4 | 14 | 4 | 10 | ||
ENE | Absent | 42 | 16 | 26 | 0.11* |
Present | 15 | 2 | 13 | ||
PORT/CRT | Absent | 41 | 14 | 27 | 0.25 |
Present | 16 | 4 | 12 | ||
Anamnestic SCC | Absent | 42 | 17 | 25 | 0.02* |
Present | 15 | 1 | 14 |