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Table 1 Included study characteristics

From: Relationship between the extent of resection and the survival of patients with low-grade gliomas: a systematic review and meta-analysis

Study Publication Time Years of Patient Accrual Country Study Type No. of Patients No. of Analysis Median Follow Up Histology Adjuvant Therapies EOR assessment Level of Evidence
WINGE(9) 1989 1982–1987 London retrospective study 285 187 NS Glioblastoma multiforme 188
Astrocytoma 76
Mixed 11
Oligodendroglioma 10
Astrocytoma or mixed A > O 32
RT NS II
Shaw(10) 2002 1986–1994 Mayo retrospective study 203 203 6.4 years Oligodendroglioma or mixed O > A 69 RT NS II
HARMON J(11) 1993 1980–1985 USA (Michigan) prospective randomized trial 60 60 4.5 years Low-grade Glioma RT + Ch NS II
Edward G(12) 1994 1960–1982 Mayo retrospective study 71 71 15 years Oligoastrocytoma RT operative report II
R. Laws(13) 1984 1915–1975 Mayo retrospective study 851 461 15 year
MAX
Astrocytoma RT microscopically III
LINDEGAARD(14) 1987 1953–1977 Norway retrospective study 58 58 23 years
MAX
Oligodendroglioma RT NS III
SHAW(a)(15) 1989 1915–1975 Mayo retrospective study 41 41 25 years
MAX
Astrocytoma RT operative report III
Soffietti(16) 1989 1950–1982 Italy retrospective study 71 71 7 year
MAX
Astrocytoma RT Surgeon’s description III
North(17) 1990 1975–1984 USA(Baltimore) retrospective study 32 32 69mo Astrocytoma RT NS III
SHAW(18) 1992 1960–1982 Mayo retrospective study 82 82 7.1 years Oligodendroglioma RT operative report III
Shibamofo(19) 1993 1965–1989 Japan (Kyoto) retrospective study 67 67 10 year
MAX
Astrocytoma RT + Ch NS III
Paolo(20) 1994 1953–1986 Italy retrospective study 105 105 NS Oligodendroglioma RT operative report III
RAJAN(21) 1994 1974–1990 UK retrospective study 82 82 52mo Glioma RT operative report III
Veelen(22) 1998 1975–1989 Netherlands retrospective study 90 90 120mo
Max
Astro 72
Oligo 14
Mixed 4
RT patients’ charts III
IWABUCHI(23) 1999 1967–1993 Japan retrospective study 56 56 5 year Astrocytoma RT NS III
Smith(24) 2008 1989–2005 USA (California) retrospective study 216 216 4.4 years Astrocytoma 93
Oligodendroglioma 91
Mixed Oligoastrocytoma 32
RT + Ch Patientrecords III
Thomas B. Daniels(25) 2012 1984–2007 Japan retrospective study 42 42 NS Astrocytoma 27
Oligodendroglioma12
Oligoastrocytoma7
RT + Ch Pre- and post-operative CT III
Nicolato(26) 1995 1977–1989 Italy retrospective study 76 74 160mo
Max
Astrocytoma RT NS IV
Jeremica(27) 1998 1988–1993 Japan retrospective study 37 37 74mo Astrocytoma 18
Oligodendroglioma 14
Mixed glioma 5
RT operative report IV
YEH(28) 2005 1985–1997 China (Taiwan) retrospective study 93 93 110mo Astrocytoma 46
Oligodendroglioma 32
Mixed 15
RT operative report IV
  1. Note: NS Not stated, RT Radiation therapy, Ch chemotherapy not otherwise specified