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Table 2. GO and KEGG pathway analysis of 17 KEAP1-NRF2-CUL3 axis regulated genes in HNSCC

From: Gene-expression signature regulated by the KEAP1-NRF2-CUL3 axis is associated with a poor prognosis in head and neck squamous cell cancer

Term p-value Genes
GO_Biological Proceess (GO_BP)
 GO:0044597~daunorubicin metabolic process 3.22E-08 AKR1C3, AKR1C2, AKR1B10, AKR1C1
 GO:0044598~doxorubicin metabolic process 3.22E-08 AKR1C3, AKR1C2, AKR1B10, AKR1C1
 GO:0055114~oxidation-reduction process 3.29E-07 AKR1C3, AKR1C2, G6PD, AKR1B10, OSGIN1, TXNRD1, AKR1C1, SRXN1
 GO:0071395~cellular response to jasmonic acid stimulus 4.46E-06 AKR1C3, AKR1C2, AKR1C1
 GO:0042448~progesterone metabolic process 2.67E-05 AKR1C3, AKR1C2, AKR1C1
 GO:0006979~response to oxidative stress 1.18E-04 GCLC, GCLM, SRXN1, SLC7A11
 GO:0008202~steroid metabolic process 6.58E-04 AKR1C3, AKR1C2, AKR1B10
KEGG Pathway
 hsa00480:Glutathione metabolism 5.9956E-05 GSTM3, G6PD, GCLC, GCLM
 hsa00140:Steroid hormone biosynthesis 0.00362777 AKR1C3, AKR1C2, AKR1C1
 hsa00980:Metabolism of xenobiotics by cytochrome P450 0.00584594 AKR1C2, GSTM3, AKR1C1