Acacia hydaspica ethyl acetate extract protects against cisplatin-induced DNA damage, oxidative stress and testicular injuries in adult male rats

Table 3 Effect of cisplatin (CP) and different treatments of AHE on testicular tissue antioxidant enzymes

Group	POD (U/min)	SOD (U/mg protein)	CAT (U/min)	QR (nM/min/mg protein)
Control	14.95 ± 0.34	1.413 ± 0.02	17.35 ± 0.16	141.7 ± 0.87
CP	8.92 ± 0.35^***	0.787 ± 0.03^***	10.48 ± 0.153^***	94.26 ± 0.78^***
AHE alone	15.13 ± 0.29⁺⁺⁺	1.402 ± 0.014⁺⁺⁺	17.95 ± 0.167⁺⁺⁺	142.3 ± 0.754⁺⁺⁺
CP + AHE	10.68 ± 0.37^***,++,###	1.012 ± 0.031^***,++,###	12.24 ± 0.152^***,+++,###	101.9 ± 0.909^***,+++,###
AHE + CP	13.42 ± 0.22^*,+++	1.377 ± 0.061⁺⁺⁺	16.91 ± 0.194⁺⁺⁺	137.6 ± 0.974^*,+++
CP + Sily	13.504 ± 0.23^*,+++	1.321 ± 0.026⁺⁺⁺	16.97 ± 0.20⁺⁺⁺	137.4 ± 0.755^*.+++

n = 6/group; values are expressed as mean ± SEM; ^{*, **, ***} indicate significance from the control group at p < 0.05, p < 0.001 and p < 0.0001 probability level, respectively; ^{++, +++} indicate significance from the CP group at p < 0.001and p < 0.0001 probability level, respectively; ### indicates comparison of AHE + CP pre-treated group vs. CP + AHE post treated group at p < 0.0001 probability level. Non-significant difference (p > 0.05) was recorded between control and AHE alone treated group in all parameters. (One way ANOVA followed by Tukeys multiple comparison tests)

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