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Table 2 Clinical and laboratory data from SCLC patients stratified by NLR

From: High neutrophil-to-lymphocyte ratios confer poor prognoses in patients with small cell lung cancer

Variables

NLR ≤ 4.55

 

NLR > 4.55

 

p value

  

n

 

n

 

Age (years, ± SD)

57.61 ± 10.63

107

60.81 ± 9.70

32

0.129

Gender (male/female)

81/26

107

26/6

32

0.513

Stage (LD/ED)

50/57

107

6/26

32

0.005**

Metastasis (yes/no)

80/27

107

28/4

32

0.129

Brain metastasis (yes/no)

7/100

107

2/30

32

1.000

Bone metastasis (yes/no)

9/98

107

6/26

32

0.111

Liver metastasis (yes/no)

11/96

107

9/23

32

0.020*

Adrenal metastasis (yes/no)

10/97

107

4/28

32

0.738

Pleural metastasis (yes/no)

7/100

107

5/27

32

0.147

Lymph node metastasis (yes/no)

72/35

107

27/5

32

0.061

Mediastinal metastasis (yes/no)

3/104

107

1/31

32

1.000

Smoking (never/ever)

32/75

107

7/25

32

0.375

Smoking amount (BI)

660 (380–970)

73

860 (600–1200)

25

0.031*

Family cancer history (yes/no)

19/48

67

8/12

20

0.323

Exposure to cooking oil fume (never/ever)

32/31

63

7/12

19

0.286

Operation (yes/no)

12/95

107

2/30

32

0.413

Radiotherapy (yes/no)

52/55

107

9/23

32

0.041*

Chemotherapy (yes/no)

96/11

107

24/8

32

0.043*

PLR

115 (89–165)

107

221 (175–324)

32

0.000***

RBC (1012/L)

4.49 (4.17–4.88)

107

4.18 (3.47–4.47)

32

0.002**

Hb (g/L)

135 (124–146)

107

120 (106–134)

32

0.001**

MCV (fL)

91.4 (87.8–94.1)

107

92.2 (87.6–93.8)

32

0.906

PLT (109/L)

181 (138–228)

107

206 (169–289)

32

0.035*

WBC (109/L)

6.13 (5.07–7.23)

107

7.34 (6.34–9.75)

32

0.001**

Neutrophil (109/L)

4.08 (3.00–4.98)

107

5.62 (4.98–7.58)

32

0.000***

Lymphocyte (109/L)

1.46 (1.22–1.82)

107

0.96 (0.71–1.10)

32

0.000***

Alb (g/L)

41.2 (38.6–43.6)

104

37.1 (33.0–40.2)

32

0.000***

LDH (U/L)

193 (175–238)

102

264 (205–360)

31

0.001**

ALP (U/L)

79 (65–95)

104

82 (59–114)

32

0.595

CHO (mmol/L)

4.46 (4.06–4.90)

102

3.87 (3.30–4.47)

31

0.000***

TG (mmol/L)

1.22 (0.88–1.45)

102

1.06 (0.87–1.46)

31

0.661

HDL-C (mmol/L)

1.25 (1.08–1.54)

102

1.09 (0.94–1.34)

31

0.007**

LDL-C (mmol/L)

2.63 (2.27–3.00)

102

2.23 (1.63–2.72)

31

0.001**

CR (μmol/L)

76.1 (65.3–87.9)

104

67.6 (55.4–83.7)

32

0.082

CEA (ng/ml)

3.71 (1.80–9.13)

85

3.66 (2.04–10.25)

29

0.747

CYFRA21-1 (ng/ml)

3.10 (2.27–4.84)

75

4.76 (2.78–7.43)

26

0.017*

NSE (ng/ml)

38.85 (22.86–97.62)

86

71.29 (37.66–113.23)

26

0.034*

  1. The data are presented as the means ± the SDs or medians (first quartile-third quartile)
  2. *p < 0.05, **p < 0.01, ***p < 0.001
  3. BI Brinkman index, which was calculated by multiplying the number of cigarettes smoked per day by the duration of smoking in years
  4. RBC red blood cell
  5. HB hemoglobin
  6. MCV mean cell volume
  7. PLT platelet
  8. WBC white blood cell
  9. Alb albumin
  10. LDH lactate dehydrogenase
  11. ALP alkaline phosphates
  12. CHO cholesterol
  13. TG triglyceride
  14. HDL-C high density lipoprotein-cholesterol
  15. LDL-C low density lipoprotein-cholesterol
  16. CR creatinine
  17. CEA carcinoembryomic antigen
  18. CYFRA21-1 cytokeratin fragment antigen 21–1
  19. NSE neuron specific enolase