Measure | Pre-CB-EST | Post CB-EST | 3 months | ANOVA, Effect size (ES) | Pre to post [95% CI] | Pre to 3 m [95% CI] | Post to 3 m [95% CI] |
---|---|---|---|---|---|---|---|
MDADI | n = 25 (100%) | n = 23 (92%) | n = 24 (96%) | ||||
53.1 (15.1) | 61.2 (15.6) | 61.8 (16.0) | p = 0.002 (2,42) F = 8.8 ES = 0.29* | p = 0.03 [0.7–15.5] | p = 0.003 [2.6–14.6] | p = 1.0 [3.6–4.7] | |
QLQ-C30 | n = 25 (100%) | n = 22 (88%) | n = 19 (76%) | ||||
Physical | 63.7 (21.8) | 74.1 (21.9) | 74.4 (21.8) | p = 0.006 (2,34) F = 5.9 ES = 0.26 | p = 0.05 [0.1–28.8] | p = 0.03 [0.7–20.8] | p = 1.0 [−8.1–7.2] |
Role | 48.1(38.3) | 61.1(34.7) | 72.2(34.3) | p = 0.03 (1,20) F = 4.8 ES = 0.22* | p = 0.5 [10.9–36.8] | p = 0.06 [1.2–49.4] | p = 0.01 [2.3–19.9] |
Emotional | 67.6 (31.0) | 75.9 (31.7) | 75.4 (24.8) | p = 0.15 (1,17) F = 2.3 ES = 0.11 | p = 0.06 [0.4–17.1] | p = 0.4 [5.9–21.7] | p = 1.0 [11.9–12.9] |
Cognitive | 70.4 (34.6) | 75.9 (34.9) | 87.0 (19.4) | p = 0.06 (2,21) F = 3.8 ES = 0.18* | p = 0.2 [2.4–13.5] | p = 0.1 [2.6–35.9] | p = 0.4 [7.8–30.0] |
Social | 44.4 (37.0) | 65.7 (36.8) | 62.9 (36.8) | p = 0.004 (2,34) F = 6.5 ES = 0.28 | p = 0.03 [1.1–41.4] | p = 0.01 [3.8–33.2] | p = 1.0 [12.9–18.5] |
Symptoms | |||||||
Fatigue | 40.7(24.9) | 33.9 (26.8) | 26.5(25.6) | p = 0.02 (2,34) F = 4.2 ES = 0.2 | p = 0.79 [8.8–22.4] | p = 0.02 [1.4–27.0] | p = 0.2 [2.7–17.5] |
Nausea | 12.9 (25.9) | 5.5 (9.9) | 8.3 (17.4) | p = 0.2 (2,34) F = 1.6 ES = 0.1 | p = 0.41 [5.1–19.9] | p = 0.86 [−6.5–15.8] | p = 1.0 [−11.7–6.2] |
Pain | 31.5 (32.3) | 29.9 (34.8) | 26.8 (30.3) | p = 0.71 (2,34) F = 0.3 ES = 0.02 | p = 1.0 [14.4–25.5] | p = 1.0 [18.5–27.7] | p = 1.0 [12.7–14.5] |
QLQ-H&N35 | n = 25 (100%) | n = 22 (88%) | n = 22 (88%) | ||||
Oral pain | 32.2 (19.8) | 23.3 (22.7) | 27.1 (21.9) | p = 0.29 (2,38) F = 1.3, ES = 0.06 | p = 0.29 [−4.0–19.8] | p = 1.0 [−9.8–17.5] | p = 1.0 [−17.3–9.8] |
Swallow | 45.8 (31.2) | 35.0 (26.0) | 28.3 (18.2) | p = 0.006 (2,38) F = 5.9, ES = 0.24 | p = 0.2 [−4.1–25.7] | p = 0.01 [3.8–31.1] | p = 0.46 [−5.1–18.4] |
Senses | 45.5 (29.4) | 32.5 (21.2) | 22.5 (26.6) | p < 0.0001 (2,38) F = 10.7, ES = 0.36 | p = 0.09 [−1.8–21.2] | p = 0.003 [6.3–33.7] | p = 0.02 [1.4–18.6] |
Speech | 40.8 (35.6) | 28.3 (35.9) | 20.8 (22.8) | p = 0.01 (2,38) F = 5.1, ES = 0.21 | p = 0.02 [1.1–28.9] | p = 0.04 [0.8–39.2] | p = 0.89 [−10.9–25.8] |
Social eating | 58.7 (37.8) | 36.1(27.0) | 38.3 (35.1) | p = 0.006 (2,38) F = 5.9, ES = 0.24 | p = 0.03 [1.2–44.1] | p = 0.05 [−0.5–41.4] | p = 1.0 [−16.0–11.6] |
Social context | 31.0 (25.9) | 16.3 (22.7) | 15.7 (17.5) | p = 0.001 (2,38) F = 9.0, ES = 0.32 | p = 0.01 [2.7–26.6] | p = 0.004 [4.5–26.1] | p = 1.0 [−8.6–9.9] |
Sexuality | 53.3 (44.1) | 48.3 (46.2) | 35.0 (46.1) | p = 0.12 (2,38) F = 0.23, ES = 0.11 | p = 1.0 [−21.8–31.8] | p = 0.06 [−0.7–37.4] | p = 0.47 [−10.3–37.0] |
CFS | n = 25 (100%) | n = 24 (96%) | n = 22 (88%) | ||||
20.3 (5.0) | 16.2 (6.8) | 15.9 (5.9) | p = 0.002 (2,42) F = 7.3, ES = 0.39 | p = 0.04 [0.1–8.1] | p = 0.04 [0.1–8.1] | p = 1.0 [2.5–2.9] | |
WASA | n = 25 (100%) | n = 23 (92%) | n = 22 (88%) | ||||
20.0 (9.2) | 13.9(11.6) | 16.9 (22.5) | p = 0.34(2,40) F = 1.1, ES = 0.05* | p = 0.07 [0.5–12.7] | p = 1.0 [9.2–15.3] | p = 1.0 [9.2–15.3] | |
HADS | n = 25 (100%) | n = 23 (92%) | n = 22 (88%) | ||||
Anxiety | 6.9 (4.9) | 6.6 (5.9) | 5.9 (4.1) | p = 0.54 (2,38) F = 0.6, ES = 0.03 | p = 1.0 [−1.8–2.7] | p = 0.8 [−1.4–3.3] | p = 1.0 [−1.6–2.6] |
Depression | 6.0 (3.4) | 5.6 (4.1) | 4.9(4.1) | p = 0.49 (2,38) F = 0.7, ES = 0.37 | p = 1.0 [−2.0–2.8] | p = 0.78 [−1.4–3.6] | p = 1.0 [−1.6–3.0] |
Total | 12.8 (7.1) | 12.0 (9.6) | 10.8 (3.4) | p = 0.38 (2,38) F = 1.0, ES = 0.05 | p = 1.0 [−2.9–4.6] | p = 0.58 [−1.9–6.0] | p = 1.0 [−2.7–5.1] |
PSS Diet | n = 25 (100%) | n = 25 (100%) | n = 24 (96%) | ||||
39.2 (19.9) | 55.0 (14.4) | 61.3 (18.5) | p < 0.0001 (2,46) F = 15.0, ES = 0.4* | p = 0.002 [5.3–26.4] | p = 0.001 [8.3–35.8] | p = 0.8 [0.4–12.9] | |
Feeding tube | n = 30 | n = 25 | n = 25 | ||||
None | 14 (56%) | 22 (88%) | 22 (88%) | ||||
Nasogastric | 9 (30%) | 1 (4%) | 0 | ||||
Gastrostomy | 7 (24%) | 2 (8%) | 3 (12%) |