Table 3 Baseline serum cytokines in Cohort 2 (sorafenib-treated patients)
Cytokines (pg/mL, mean ± SE) | Survival time ≥ 2 years(n = 7) | Survival time < 2 years(n = 32) | P-valuea |
|---|---|---|---|
EGF | 213.7 ± 99.5 | 58.3 ± 10.6 | 0.004 |
FGF | 89.6 ± 46.8 | 103.4 ± 19.4 | 0.770 |
HGF | 483.4 ± 111.9 | 313.0 ± 45.8 | 0.133 |
IFN-γ | 23.2 ± 4.2 | 16.0 ± 1.8 | 0.103 |
IL-10 | 32.1 ± 10.6 | 16.2 ± 1.7 | 0.012 |
IL-12 (p70) | 23.0 ± 4.3 | 14.6 ± 1.6 | 0.039 |
IL-2 | 50.8 ± 12.0 | 34.1 ± 3.7 | 0.093 |
IL-4 | 18.9 ± 3.5 | 13.2 ± 1.5 | 0.132 |
IL-5 | 20.3 ± 4.8 | 14.4 ± 2.1 | 0.246 |
IL-6 | 25.2 ± 7.5 | 18.2 ± 2.4 | 0.270 |
IL-8/CXCL8 | 80.1 ± 36.3 | 37.1 ± 5.5 | 0.039 |
CXCL10 | 1078.6 ± 339.9 | 631.9 ± 116.2 | 0.136 |
CXCL9 | 345.3 ± 65.8 | 241.8 ± 32.1 | 0.178 |
PDGF-BB | 620.6 ± 250.4 | 171.0 ± 31.6 | 0.001 |
SCF | 78.9 ± 12.8 | 48.0 ± 5.3 | 0.021 |
SDF-1 | 876.0 ± 148.1 | 549.1 ± 54.1 | 0.020 |
TGF-β | 32.4 ± 6.4 | 23.2 ± 2.5 | 0.143 |
TGF-α | 31.6 ± 11.5 | 16.2 ± 1.8 | 0.020 |
TNF-α | 22.9 ± 8.0 | 13.0 ± 1.4 | 0.042 |
VEGF-A | 94.6 ± 10.2 | 86.7 ± 17.9 | 0.841 |