Table 3 Association of GWAS-identified single-nucleotide polymorphisms on risk of colorectal cancer by smoking behaviors
From: Effects of interactions between common genetic variants and smoking on colorectal cancer
SNP/genotype | Case | Control | ORa | (95% CI) | Case | Control | ORa | (95% CI) | P interaction b | FDR-corrected P interaction | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N | (%) | N | (%) | N | (%) | N | (%) | |||||||
Men | ||||||||||||||
 Smoking status x rs1957636 | never smoker (N = 307) | ever smoker (N = 1133) |  |  | ||||||||||
  TT | 47 | (40.5) | 54 | (28.3) | 1.00 | (ref.) | 113 | (31.0) | 285 | (37.1) | 1.00 | (ref.) | 5.5 × 10−4 | 1.8 × 10−3 |
  CT | 54 | (46.6) | 100 | (52.4) | 0.62 | (0.35–1.08) | 178 | (48.9) | 364 | (47.3) | 1.27 | (0.94–1.72) | ||
  CC | 14 | (12.1) | 37 | (19.4) | 0.36 | (0.16–0.79) | 70 | (19.2) | 118 | (15.3) | 1.51 | (1.02–2.24) | ||
  CT + TT | 68 | (58.6) | 137 | (71.7) | 0.54 | (0.32–0.92) | 248 | (68.1) | 482 | (62.7) | 1.33 | (1.00–1.77) | 1.9 × 10−3 | 0.06 |
 Smoking status x rs4813802 | never smoker (N = 307) | ever smoker (N = 1133) |  |  | ||||||||||
  TT | 61 | (52.6) | 123 | (64.4) | 1.00 | (ref.) | 222 | (61.0) | 463 | (60.2) | 1.00 | (ref.) | 0.04 | 0.55 |
  GT | 42 | (36.2) | 50 | (26.2) | 1.72 | (0.98–3.01) | 124 | (34.1) | 254 | (33.0) | 1.00 | (0.75–1.33) | ||
  GG | 7 | (6.0) | 8 | (4.2) | 1.27 | (0.40–4.06) | 8 | (2.2) | 37 | (4.8) | 0.41 | (0.18–0.94) | ||
  GT + GG | 49 | (42.2) | 58 | (30.4) | 1.65 | (0.97–2.81) | 132 | (36.3) | 291 | (37.8) | 0.92 | (0.70–1.22) | 0.05 | 0.46 |
Women | ||||||||||||||
 Smoking status x rs6687758 | never smoker (N = 626) | ever smoker (N = 43) |  |  | ||||||||||
  AA | 100 | (50.0) | 185 | (43.4) | 1.00 | (ref.) | 10 | (43.5) | 8 | (40.0) | 1.00 | (ref.) | 0.03 | 0.34 |
  AG | 69 | (34.5) | 177 | (41.6) | 0.71 | (0.47–1.06) | 7 | (30.4) | 9 | (45.0) | 1.05 | (0.20–5.54) | ||
  GG | 9 | (4.5) | 31 | (7.3) | 0.49 | (0.21–1.15) | 5 | (21.7) | 0 | (0.0) | – |  | ||
  AG + GG | 78 | (39.0) | 208 | (48.8) | 0.68 | (0.46–0.99) |  |  |  |  | 1.86 | (0.38–9.20) | 0.24 | 0.53 |
 Smoking durationc x rs174537 | ≤ 15 years (N = 22) | > 15 years (N = 21) |  |  | ||||||||||
  GG | 3 | (37.5) | 4 | (28.6) | 1.00 | (ref.) | 7 | (46.7) | 4 | (66.7) | 1.00 | (ref.) | 0.05 | 0.51 |
  GT | 2 | (25.0) | 7 | (50.0) | 1.42 | (0.05–41.81) | 5 | (33.3) | 2 | (33.3) | 0.30 | (0.01–12.01) | ||
  TT | 3 | (37.5) | 0 | (0.0) | – |  | 2 | (13.3) | 0 | (0.0) | – |  | ||
  GT + TT | 5 | (62.5) | 7 | (50.0) | 8.55 | (0.68–107.61) | 7 | (46.7) | 2 | (33.3) | 0.36 | (0.01–14.35) | 0.15 | 0.99 |
 Pack-years of smokingc x rs4813802 | < 5 pack-years (N = 19) | ≥ 5 pack-years (N = 24) |  |  | ||||||||||
  TT | 5 | (71.4) | 7 | (58.3) | 1.00 | (ref.) | 8 | (50.0) | 6 | (75.0) | 1.00 | (ref.) | 0.04 | 0.57 |
  GT | 2 | (28.6) | 5 | (41.7) | 0.48 | (0.02–13.68) | 7 | (43.8) | 2 | (25.0) | 20.42 | (0.84–499.17) | ||
  GG | 0 | (0.0) | 0 | (0.0) | – |  | 1 | (6.3) | 0 | (0.0) | – |  | ||
  GT + GG | 2 | (28.6) | 5 | (41.7) | 0.48 | (0.02–13.68) | 8 | (50.0) | 2 | (25.0) | 23.17 | (0.96–559.14) | 0.03 | 0.48 |