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Table 4 Hazard ratio (HR) of incident colorectal cancer associated with Homeostasis Model Assessment for Insulin Resistance (HOMA2-IR) for men and women in the Malmö Diet and Cancer Study cardiovascular cohort

From: High blood glucose levels are associated with higher risk of colon cancer in men: a cohort study

  Unadjusted model Full model
Quartiles of HOMA2-IR Min-max (mIU/l) Cases/person-years HR 95% CI HR 95% CI
Men (n = 1824)
 1 0.35–0.63 6/3938 1.00   1.00  
 2 0.64–0.90 9/7615 0.66 0.30, 1.47 0.64 0.29, 1.44
 3 0.91–1.28 19/8618 1.35 0.69, 2.63 1.29 0.65, 2.56
 4 1.29–6.85 30/9434 1.80 0.95, 3.41 1.62 0.81, 3.25
p for trend    0.042   0.132  
Women (n = 2627)
 1 0.34–0.51 17/9764 1.00   1.00  
 2 0.52–0.77 21/12496 1.26 0.67, 2.37 1.11 0.59, 2.09
 3 0.78–1.06 18/11908 1.15 0.60, 2.18 0.97 0.50, 1.89
 4 1.07–7.30 15/10309 0.97 0.49, 1.89 0.77 0.37, 1.59
p for trend    0.760   0.779  
  1. HR was calculated with the Cox proportional hazard regression model
  2. Unadjusted model: No adjustments made
  3. Full model: Adjusted for age (quartiles of age), BMI (≤ 25 kg/m2, > 25 kg/m2), and smoking (current, ex or never)
  4. Values are quartile ranges, hazard ratios (HR), and 95% confidence intervals (CI)