Skip to main content

Table 2 Hazard ratio (HR) of incident colorectal-, colon, and rectal cancer associated with blood glucose, plasma insulin and Homeostasis Model Assessment for Insulin Resistance (HOMA2-IR) in the Malmö Diet and Cancer Study cardiovascular cohort

From: High blood glucose levels are associated with higher risk of colon cancer in men: a cohort study

  Colorectal cancer Colon cancer   Rectal cancer
Crude model Full model   Crude model Full model   Crude model Full model
Quartiles Min-max Cases/person-years HR 95% CI HR 95% CI Cases/person-years HR 95% CI HR 95% CI Cases/person-years HR 95% CI HR 95% CI
Blood glucose (mmol/l) n = 4910
 1 3.3–4.5 25/18381 1.00   1.00   14/18246 1.00   1.00   11/18215 1.00   1.00  
 2 4.6–4.8 30/21325 1.04 0.61, 1.76 0.94 0.55, 1.60 13/21193 0.80 0.38, 1.70 0.71 0.33, 1.51 17/21197 1.33 0.62, 2.83 1.21 0.56, 2.60
 3 4.9–5.2 34/22388 1.12 0.67, 1.87 0.99 0.59, 1.68 22/22277 1.29 0.66, 2.52 1.11 0.56, 2.21 12/22163 0.89 0.39, 2.03 0.78 0.34, 1.81
 4 5.3–16.8 56/19687 2.11 1.31, 3.37 1.72 1.05, 2.84 32/19476 2.17 1.15, 4.06 1.70 0.87, 3.33 24/19360 2.05 1.00, 4.18 1.62 0.75, 3.45
p for trend   0.003   0.044    0.005   0.032    0.165   0.530  
p for interaction between sex and blood glucose    0.013      0.032      0.130  
Plasma insulin (mIU/l) n = 4910
 1 <3–4 33/23177 1.00   1.00   22/2047 1.00   1.00   11/22922 1.00   1.00  
 2 5–6 32/19306 1.16 0.72, 1.89 1.09 0.67, 1.78 17/19190 0.93 0.49, 1.75 0.85 0.45, 1.60 15/19154 1.63 0.75, 3.55 1.58 0.72, 3.45
 3 7–8 33/16926 1.37 0.84, 2.22 1.25 0.76, 2.04 20/16800 1.25 0.68, 2.29 1.09 0.59, 2.03 13/16710 1.62 0.72, 3.06 1.55 0.69, 3.52
 4 9–224 47/22372 1.48 0.95, 2.32 1.21 0.75, 1.96 22/22154 1.05 0.58, 1.89 0.80 0.42, 1.50 25/21149 2.35 1.16, 4.78 2.12 0.99, 4.53
p for trend   0.064   0.411    0.645   0.635    0.024   0.078  
p for interaction between sex and plasma insulin    0.142      0.350      0.316  
HOMA2-IR n = 4451
 1 0.3–0.5 23/13702 1.00   1.00   16/13623 1.00   1.00   7/13514 1.00   1.00  
 2 0.5–0.8 30/20111 0.98 0.59, 1.62 0.91 0.55, 1.50 16/19996 0.80 0.42, 1.53 0.72 0.37, 1.38 14/19966 1.33 0.60, 2.92 1.27 0.58, 2.82
 3 0.8–1.2 37/20527 1.19 0.74, 1.91 1.06 0.65, 1.72 22/20387 1.08 0.59, 1.96 0.92 0.50, 1.70 15/20288 1.40 0.64, 3.04 1.33 0.60, 2.95
 4 1.2–7.3 45/19776 1.51 0.96, 2.37 1.23 0.75, 2.01 22/19574 1.13 0.62, 2.06 0.84 0.44, 1.33 23/19553 2.23 1.09, 4.57 2.03 0.93, 4.42
p for trend   0.066   0.429    0.527   0.733    0.040   0.116  
p for interaction between sex and HOMA2-IR    0.099      0.211      0.789  
  1. Full model: Calculated with the Cox proportional hazard regression model. Adjusted for sex (man, woman), age (quartiles of age), BMI (≤ 25 kg/m2, > 25 kg/m2), and smoking (current, ex or never). Values are quartile ranges, hazard ratios (HR), and 95% confidence intervals (CI)