Risk factors | All Stages | Stage IIIA | ||||
---|---|---|---|---|---|---|
HR | 95% CI | p a | HR | 95% CI | p a | |
Age, years | ||||||
  < 65 | 1.00 | Reference |  | 1.00 | Reference |  |
  ≥ 65 | 1.99 | 1.70–2.33 | < .001 | 2.23 | 1.51–3.30 | < .001 |
BMI | 0.95 | 0.92–0.97 | < .001 |  |  |  |
ASA | ||||||
 I | 1.00 | Reference |  |  |  |  |
 II | 1.25 | 1.06–1.48 | 0.008 |  |  |  |
 III | 2.24 | 1.71–2.93 | < .001 |  |  |  |
pT category | ||||||
 T1 | 1.00 | Reference |  |  |  |  |
 T2 | 0.83 | 0.56–1.24 | 0.366 |  |  |  |
 T3 | 1.10 | 0.72–1.66 | 0.663 |  |  |  |
 T4 | 2.00 | 1.29–3.09 | 0.002 |  |  |  |
pN category | ||||||
 N0 | 1.00 | Reference |  |  |  |  |
 N1 | 1.44 | 1.10–1.87 | 0.007 |  |  |  |
 N2 | 1.79 | 1.36–2.35 | < .001 |  |  |  |
 N3 | 3.45 | 2.64–4.50 | < .001 |  |  |  |
Total number of LN examined | ||||||
 0–30 | 1.00 | Reference |  | 1.00 | Reference |  |
 30–45 | 1.05 | 0.86–1.28 | 0.614 | 0.87 | 0.53–1.45 | 0.580 |
  > 45 | 0.96 | 0.79–1.18 | 0.721 | 0.56 | 0.33–0.95 | 0.030 |
Tumor location | ||||||
 Proximal | 1.00 | Reference |  |  |  |  |
 Middle | 1.27 | 1.00–1.61 | 0.051 |  |  |  |
 Distal | 1.35 | 1.05–1.75 | 0.020 |  |  |  |
 Whole | 1.66 | 1.15–2.40 | 0.007 |  |  |  |
Histologic grade* | ||||||
 Differentiated | 1.00 | Reference |  |  |  |  |
 Undifferentiated | 0.85 | 0.72–1.00 | 0.045 |  |  |  |
 Others | 2.69 | 1.74–4.15 | < .001 |  |  |  |
Borrmann type | ||||||
 0 | 1.00 | Reference |  |  |  |  |
 I | 1.73 | 0.92–3.25 | 0.089 |  |  |  |
 II | 1.43 | 0.95–2.15 | 0.085 |  |  |  |
 III | 1.85 | 1.28–2.68 | 0.001 |  |  |  |
 IV | 2.27 | 1.41–3.65 | 0.001 |  |  |  |
 V | 1.29 | 0.31–5.42 | 0.732 |  |  |  |
Lymphovascular invasion | ||||||
 Absent | 1.00 | Reference |  |  |  |  |
 Present | 1.31 | 1.08–1.60 | 0.007 |  |  |  |
Resection type | ||||||
 Subtotal | 1.00 | Reference |  |  |  |  |
 Total | 1.20 | 0.98–1.49 | 0.084 |  |  |  |
 Extended | 1.55 | 1.16–2.06 | 0.003 |  |  |  |