|
Risk factors
|
All Stages
|
Stage IIIA
|
|---|
|
HR
|
95% CI
|
p
a
|
HR
|
95% CI
|
p
a
|
|---|
|
Age, years
|
|
< 65
|
1.00
|
Reference
| |
1.00
|
Reference
| |
|
≥ 65
|
1.99
|
1.70–2.33
|
< .001
|
2.23
|
1.51–3.30
|
< .001
|
|
BMI
|
0.95
|
0.92–0.97
|
< .001
| | | |
|
ASA
|
|
I
|
1.00
|
Reference
| | | | |
|
II
|
1.25
|
1.06–1.48
|
0.008
| | | |
|
III
|
2.24
|
1.71–2.93
|
< .001
| | | |
|
pT category
|
|
T1
|
1.00
|
Reference
| | | | |
|
T2
|
0.83
|
0.56–1.24
|
0.366
| | | |
|
T3
|
1.10
|
0.72–1.66
|
0.663
| | | |
|
T4
|
2.00
|
1.29–3.09
|
0.002
| | | |
|
pN category
|
|
N0
|
1.00
|
Reference
| | | | |
|
N1
|
1.44
|
1.10–1.87
|
0.007
| | | |
|
N2
|
1.79
|
1.36–2.35
|
< .001
| | | |
|
N3
|
3.45
|
2.64–4.50
|
< .001
| | | |
|
Total number of LN examined
|
|
0–30
|
1.00
|
Reference
| |
1.00
|
Reference
| |
|
30–45
|
1.05
|
0.86–1.28
|
0.614
|
0.87
|
0.53–1.45
|
0.580
|
|
> 45
|
0.96
|
0.79–1.18
|
0.721
|
0.56
|
0.33–0.95
|
0.030
|
|
Tumor location
|
|
Proximal
|
1.00
|
Reference
| | | | |
|
Middle
|
1.27
|
1.00–1.61
|
0.051
| | | |
|
Distal
|
1.35
|
1.05–1.75
|
0.020
| | | |
|
Whole
|
1.66
|
1.15–2.40
|
0.007
| | | |
|
Histologic grade*
|
|
Differentiated
|
1.00
|
Reference
| | | | |
|
Undifferentiated
|
0.85
|
0.72–1.00
|
0.045
| | | |
|
Others
|
2.69
|
1.74–4.15
|
< .001
| | | |
|
Borrmann type
|
|
0
|
1.00
|
Reference
| | | | |
|
I
|
1.73
|
0.92–3.25
|
0.089
| | | |
|
II
|
1.43
|
0.95–2.15
|
0.085
| | | |
|
III
|
1.85
|
1.28–2.68
|
0.001
| | | |
|
IV
|
2.27
|
1.41–3.65
|
0.001
| | | |
|
V
|
1.29
|
0.31–5.42
|
0.732
| | | |
|
Lymphovascular invasion
|
|
Absent
|
1.00
|
Reference
| | | | |
|
Present
|
1.31
|
1.08–1.60
|
0.007
| | | |
|
Resection type
|
|
Subtotal
|
1.00
|
Reference
| | | | |
|
Total
|
1.20
|
0.98–1.49
|
0.084
| | | |
|
Extended
|
1.55
|
1.16–2.06
|
0.003
| | | |
- Abbreviations: BMI body mass index, ASA American Society of Anesthesiology, pT pathologic tumor, pN pathologic nodal status
- †Only factors found to be statistically significant, except for total number of LN examined, reported. For all variables, refer to Additional file 4: Table S1
- ap values indicate a relative statistical significance for each category compared to the reference category in each variable (HR 1.00)
- *Differentiated histology included papillary adenocarcinoma, well-differentiated and moderately-differentiated tubular adenocarcinoma. Undifferentiated histology included poorly differentiated adenocarcinoma, signet ring cell adenocarcinoma, and mucinous carcinoma. Others included adenosquamous, squamous, neuroendocrine, etc.
