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Table 3 Multivariate analysis of clinicopathologic factors associated with overall survival

From: Effect of total number of harvested lymph nodes on survival outcomes after curative resection for gastric adenocarcinoma: findings from an eastern high-volume gastric cancer center

Risk factors All Stages Stage IIIA
HR 95% CI p a HR 95% CI p a
Age, years
  < 65 1.00 Reference   1.00 Reference  
  ≥ 65 1.99 1.70–2.33 < .001 2.23 1.51–3.30 < .001
BMI 0.95 0.92–0.97 < .001    
ASA
 I 1.00 Reference     
 II 1.25 1.06–1.48 0.008    
 III 2.24 1.71–2.93 < .001    
pT category
 T1 1.00 Reference     
 T2 0.83 0.56–1.24 0.366    
 T3 1.10 0.72–1.66 0.663    
 T4 2.00 1.29–3.09 0.002    
pN category
 N0 1.00 Reference     
 N1 1.44 1.10–1.87 0.007    
 N2 1.79 1.36–2.35 < .001    
 N3 3.45 2.64–4.50 < .001    
Total number of LN examined
 0–30 1.00 Reference   1.00 Reference  
 30–45 1.05 0.86–1.28 0.614 0.87 0.53–1.45 0.580
  > 45 0.96 0.79–1.18 0.721 0.56 0.33–0.95 0.030
Tumor location
 Proximal 1.00 Reference     
 Middle 1.27 1.00–1.61 0.051    
 Distal 1.35 1.05–1.75 0.020    
 Whole 1.66 1.15–2.40 0.007    
Histologic grade*
 Differentiated 1.00 Reference     
 Undifferentiated 0.85 0.72–1.00 0.045    
 Others 2.69 1.74–4.15 < .001    
Borrmann type
 0 1.00 Reference     
 I 1.73 0.92–3.25 0.089    
 II 1.43 0.95–2.15 0.085    
 III 1.85 1.28–2.68 0.001    
 IV 2.27 1.41–3.65 0.001    
 V 1.29 0.31–5.42 0.732    
Lymphovascular invasion
 Absent 1.00 Reference     
 Present 1.31 1.08–1.60 0.007    
Resection type
 Subtotal 1.00 Reference     
 Total 1.20 0.98–1.49 0.084    
 Extended 1.55 1.16–2.06 0.003    
  1. Abbreviations: BMI body mass index, ASA American Society of Anesthesiology, pT pathologic tumor, pN pathologic nodal status
  2. Only factors found to be statistically significant, except for total number of LN examined, reported. For all variables, refer to Additional file 4: Table S1
  3. ap values indicate a relative statistical significance for each category compared to the reference category in each variable (HR 1.00)
  4. *Differentiated histology included papillary adenocarcinoma, well-differentiated and moderately-differentiated tubular adenocarcinoma. Undifferentiated histology included poorly differentiated adenocarcinoma, signet ring cell adenocarcinoma, and mucinous carcinoma. Others included adenosquamous, squamous, neuroendocrine, etc.