Evaluation of plasma brain-derived neurotrophic factor levels and self-perceived cognitive impairment post-chemotherapy: a longitudinal study

Ng, Terence; Lee, Ying Yun; Chae, Jung-woo; Yeo, Angie Hui Ling; Shwe, Maung; Gan, Yan Xiang; Ng, Raymond C. H.; Chu, Pat Pak Yan; Khor, Chiea Chuen; Ho, Han Kiat; Chan, Alexandre

doi:10.1186/s12885-017-3861-9

Table 3 Association between proportion of individuals with self-perceived cognitive impairment and plasma BDNF levels (n = 51)

From: Evaluation of plasma brain-derived neurotrophic factor levels and self-perceived cognitive impairment post-chemotherapy: a longitudinal study

Variable	Proportion of individuals with cognitive impairment^a		FACT-Cog domains^b
	Proportion of individuals with cognitive impairment^a		Mental Acuity		Concentration		Memory		Verbal		Functional		Multi-tasking
	Coefficient (SE)	p value^c	Coefficient (SE)	p value^c	Coefficient (SE)	p value^c	Coefficient (SE)	p value^c	Coefficient (SE)	p value^c	Coefficient (SE)	p value^c	Coefficient s(SE)	p value^c
BDNF^d	0.0001 (0.00007)	0.108	−0.00004 (0.0001)	0.669	0.00005 (0.00002)	0.032	−0.00003 (0.00009)	0.732	0.00005 (0.00007)	0.511	−0.00006 (0.0001)	0.617	0.00009 (0.00006)	0.138
BFI	0.339 (0.234)	0.147	0.096 (0.250)	0.700	−0.367 (0.067)	<0.001	0.652 (0.249)	0.009	0.314 (0.222)	0.157	0.708 (0.345)	0.040	0.274 (0.190)	0.149
BAI	0.241 (0.072)	0.001	0.275 (0.082)	0.001	−0.042 (0.021)	0.047	0.201 (0.074)	0.007	0.247 (0.072)	0.001	0.308 (0.112)	0.006	0.196 (0.059)	0.001
BDI	−0.005 (0.085)	0.949	−0.010 (0.093)	0.912	−0.063 (0.027)	0.018	−0.090 (0.097)	0.355	−0.079 (0.089)	0.370	−0.116 (0.123)	0.343	−0.033 (0.077)	0.667
Age	0.037 (0.044)	0.403	0.010 (0.044)	0.830	0.011 (0.025)	0.669	−0.010 (0.051)	0.848	0.027 (0.045)	0.550	−0.009 (0.065)	0.888	0.037 (0.044)	0.397
BMI	0.141 (0.076)	0.064	0.148 (0.078)	0.056	−0.006 (0.048)	0.907	0.116 (0.082)	0.156	0.097 (0.078)	0.213	0.152 (0.094)	0.105	0.078 (0.077)	0.312
BDNF genotype^e	−1.191 (0.582)	0.041	−0.543 (0.582)	0.351	−0.658 (0.326)	0.043	−0.233 (0.698)	0.738	−0.811 (0.591)	0.170	−0.400 (0.887)	0.652	−0.698 (0.554)	0.208
Constant	−8.570 (3.628)	0.018	−7.600 (3.825)	0.047	16.035 (1.764)	<0.001	−6.742 (4.023)	0.094	−6.655 (3.645)	0.068	−8.930 (5.134)	0.082	−6.746 (3.546)	0.057

Abbreviation: SE standard error, BFI Brief Fatigue Inventory, BAI Brief Anxiety Inventory, BDI Beck Depression Inventory, BMI body mass index
^aProportion of individuals with cognitive impairment is estimated based on the Minimal Clinically Important Difference of the global FACT-Cog score. Patients with a FACT-Cog score of more than −10.6 points from baseline were classified as having cognitive impairment
^bProportion of individuals with impairment at the respective domains is determined by a MCID of 15% decrease in the FACT-Cog subdomain scores from baseline
^cBolded p values indicate statistical significance
^dPlasma BDNF levels were ranged in pg/mL
^eReference genotype is Val/Val

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ISSN: 1471-2407

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