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Table 2 SIRT2 deletion versus clinicopathological outcomes in the prostate cancer TCGA database (n = 499)

From: Dysregulation of Sirtuin 2 (SIRT2) and histone H3K18 acetylation pathways associates with adverse prostate cancer outcomes

 

SIRT2 Deleted (n = 30)

SIRT2 Diploid (n = 452)

P

Age (Median/IQR)

64(61.75–66.75)

61(56–66)

 

TNM stage

 T1

0

2(0.4%)

 

 T2

5(16.67%)

164(40.2%)

 

 T3

22(73.34%)

276(61.2%)

 

 T4

3(10%)

9(2%)

0.01 a

 N1

8(27%)

79(17.4%)

0.22

 M+

 

3

 

Recurrence

 Yes

10(33.34%)

81(17.9%)

 

 No

15(50%)

290(64%)

0.04 a

Bilateral

29(96%)

435(96%)

1

LNDa dissection

29(96%)

421(90%)

0.7

Nodes (Median/IQR)

7(4–16)

9(5–16)

 

Positive margins

16(53%)

152(33.6%)

0.04 a

Complete remission

9 (30%)

164(33.6%)

0.8

Partial remission

4 (13%)

29(6.4%)

0.14

Biochemical relapse

3 (20%)

48(10.6%)

0.13

  1. aClinicopathological outcomes were compared between patients with diploid and deleted SIRT2. Patients with SIRT2 deletion had higher clinical ‘T’ stage, increased chance of recurrence and greater odds of positive surgical margins