| |
SIRT2 Deleted (n = 30)
|
SIRT2 Diploid (n = 452)
|
P
|
|---|
|
Age (Median/IQR)
|
64(61.75–66.75)
|
61(56–66)
| |
|
TNM stage
|
|
T1
|
0
|
2(0.4%)
| |
|
T2
|
5(16.67%)
|
164(40.2%)
| |
|
T3
|
22(73.34%)
|
276(61.2%)
| |
|
T4
|
3(10%)
|
9(2%)
|
0.01
a
|
|
N1
|
8(27%)
|
79(17.4%)
|
0.22
|
|
M+
| |
3
| |
|
Recurrence
|
|
Yes
|
10(33.34%)
|
81(17.9%)
| |
|
No
|
15(50%)
|
290(64%)
|
0.04
a
|
|
Bilateral
|
29(96%)
|
435(96%)
|
1
|
|
LNDa dissection
|
29(96%)
|
421(90%)
|
0.7
|
|
Nodes (Median/IQR)
|
7(4–16)
|
9(5–16)
| |
|
Positive margins
|
16(53%)
|
152(33.6%)
|
0.04
a
|
|
Complete remission
|
9 (30%)
|
164(33.6%)
|
0.8
|
|
Partial remission
|
4 (13%)
|
29(6.4%)
|
0.14
|
|
Biochemical relapse
|
3 (20%)
|
48(10.6%)
|
0.13
|
-
aClinicopathological outcomes were compared between patients with diploid and deleted SIRT2. Patients with SIRT2 deletion had higher clinical ‘T’ stage, increased chance of recurrence and greater odds of positive surgical margins
